Dissecting the polygenic contribution of attention-deficit/hyperactivity disorder and autism spectrum disorder on school performance by their relationship with educational attainment
Por:
Cabana-Domínguez J, Bosch R, Soler Artigas M, Alemany S, Llonga N, Vilar-Ribó L, Carabí-Gassol P, Arribas L, Macias-Chimborazo V, Español-Martín G, Del Castillo C, Martínez L, Pagerols M, Èlia Pagespetit Feliu, Prat R, Puigbó J, Ramos-Quiroga JA, Casas M and Ribasés M
Publicada:
1 nov 2024
Ahead of Print:
1 may 2024
Resumen:
Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) are strongly associated with educational attainment (EA), but little is known about their genetic relationship with school performance and whether these links are explained, in part, by the genetic liability of EA. Here, we aim to dissect the polygenic contribution of ADHD and ASD to school performance, early manifestation of psychopathology and other psychiatric disorders and related traits by their relationship with EA. To do so, we tested the association of polygenic scores for EA, ADHD and ASD with school performance, assessed whether the contribution of the genetic liability of ADHD and ASD to school performance is influenced by the genetic liability of EA, and evaluated the role of EA in the genetic overlap between ADHD and ASD with early manifestation of psychopathology and other psychiatric disorders and related traits in a sample of 4,278 school-age children. The genetic liability for ADHD and ASD dissected by their relationship with EA show differences in their association with school performance and early manifestation of psychopathology, partly mediated by ADHD and ASD symptoms. Genetic variation with concordant effects in ASD and EA contributes to better school performance, while the genetic variation with discordant effects in ADHD or ASD and EA is associated with poor school performance and higher rates of emotional and behavioral problems. Our results strongly support the usage of the genetic load for EA to dissect the genetic and phenotypic heterogeneity of ADHD and ASD, which could help to fill the gap of knowledge of mechanisms underlying educational outcomes.
Filiaciones:
Cabana-Domínguez J:
Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
Department of Mental Health, Hospital Universitari Vall d'Hebron, Barcelona, Spain
Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain
Bosch R:
Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain
SJD MIND Schools Program, Hospital Sant Joan de Déu, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain
Soler Artigas M:
Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
Department of Mental Health, Hospital Universitari Vall d'Hebron, Barcelona, Spain
Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain
Department of Genetics, Microbiology, and Statistics, Faculty of Biology, Universitat de Barcelona (UB), Barcelona, Spain
Alemany S:
Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
Department of Mental Health, Hospital Universitari Vall d'Hebron, Barcelona, Spain
Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain
Llonga N:
Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
Department of Mental Health, Hospital Universitari Vall d'Hebron, Barcelona, Spain
Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain
Department of Genetics, Microbiology, and Statistics, Faculty of Biology, Universitat de Barcelona (UB), Barcelona, Spain
Vilar-Ribó L:
Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
Department of Mental Health, Hospital Universitari Vall d'Hebron, Barcelona, Spain
Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain
Carabí-Gassol P:
Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
Department of Mental Health, Hospital Universitari Vall d'Hebron, Barcelona, Spain
Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain
Department of Genetics, Microbiology, and Statistics, Faculty of Biology, Universitat de Barcelona (UB), Barcelona, Spain
Arribas L:
Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
Department of Mental Health, Hospital Universitari Vall d'Hebron, Barcelona, Spain
Macias-Chimborazo V:
Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
Department of Mental Health, Hospital Universitari Vall d'Hebron, Barcelona, Spain
Español-Martín G:
Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
Department of Mental Health, Hospital Universitari Vall d'Hebron, Barcelona, Spain
Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain
Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
Del Castillo C:
SJD MIND Schools Program, Hospital Sant Joan de Déu, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain
Martínez L:
SJD MIND Schools Program, Hospital Sant Joan de Déu, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain
Pagerols M:
Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain
SJD MIND Schools Program, Hospital Sant Joan de Déu, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain
Department of Clinical Foundations, Faculty of Medicine and Health Sciences, Universitat de Barcelona (UB), Barcelona, Spain
Èlia Pagespetit Feliu:
SJD MIND Schools Program, Hospital Sant Joan de Déu, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain
Department of Medicine, Faculty of Medicine, Universitat de Vic-Universitat Central de Catalunya (UVic-UCC), Vic, Spain
Prat R:
Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain
SJD MIND Schools Program, Hospital Sant Joan de Déu, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain
Sport and Physical Activity Research Group, Mental Health and Social Innovation Research Group, Centre for Health and Social Care Research (CEES), Universitat de Vic-Universitat Central de Catalunya (UVic-UCC), Vic, Spain
Puigbó J:
SJD MIND Schools Program, Hospital Sant Joan de Déu, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain
Ramos-Quiroga JA:
Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
Department of Mental Health, Hospital Universitari Vall d'Hebron, Barcelona, Spain
Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain
Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
Casas M:
SJD MIND Schools Program, Hospital Sant Joan de Déu, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain
Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
Fundació Privada d'Investigació Sant Pau (FISP), Barcelona, Spain
Ribasés M:
Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
Department of Mental Health, Hospital Universitari Vall d'Hebron, Barcelona, Spain
Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain
Department of Genetics, Microbiology, and Statistics, Faculty of Biology, Universitat de Barcelona (UB), Barcelona, Spain
Univ Autonoma Barcelona, Vall dHebron Res Inst VHIR, Psychiat Genet
Unit, Grp Psychiat Mental Hlth & Addict, Barcelona, Spain
Hosp Univ Vall dHebron, Dept Mental Hlth, Barcelona, Spain
Biomed Network Res Ctr Mental Hlth CIBERSAM, Madrid, Spain
Hosp St Joan de Deu, Inst Recerca St Joan de Deu, SJD MIND Sch Program,
Esplugas de Llobregat, Spain
Univ Barcelona UB, Fac Biol, Dept Genet Microbiol & Stat, Barcelona,
Spain
Univ Autonoma Barcelona UAB, Dept Psychiat & Forens Med, Barcelona,
Univ Barcelona UB, Dept Clin Fdn, Fac Med & Hlth Sci, Barcelona, Spain
Univ Vic Univ Cent Catalunya UVic UCC, Fac Med, Dept Med, Vic, Spain
Univ Vic Univ Cent Catalunya UVic UCC, Ctr Hlth & Social Care Res CEES,
Sport & Phys Act Res Grp, Mental Hlth & Social Innovat Res Grp, Vic,
Fundacio Privada Invest St Pau FISP, Barcelona, Spain
Green Submitted, hybrid
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