Unraveling neural adaptation to vocal and non-vocal sounds in autism.
Por:
Merchie A, Bonnet-Brilhault F, Escera C, Houy-Durand E and Gomot M
Publicada:
1 feb 2025
Ahead of Print:
11 dic 2024
Resumen:
OBJECTIVE: Autism is linked to a strong need for sameness and difficulties in social communication, associated with atypical brain responses to voices and changes. This study aimed to characterize neural adaptation in autistic adults using a Roving paradigm and assess how vocal vs. non-vocal, as well as neutral vs. emotional sounds, influence this adaptation. METHODS: Neural adaptation was measured in 20 autistic and 20 non-autistic adults using a Roving paradigm, where sounds were repeated 4, 8, or 14 times. Neural responses and Repetition Positivity (RP) amplitudes were analyzed as indices of adaptation. RESULTS: RP amplitudes showed no significant differences between groups for vocal or non-vocal sounds, but adaptation dynamics varied. Non-autistic adults adapted more quickly to non-vocal (5-8 repetitions) compared to vocal sounds (12-14 repetitions). In contrast, autistic adults adapt faster to vocal than to non-vocal sounds. Moreover emotional prosodic content influenced RP amplitude in autistic adults only, suggesting heightened sensitivity to emotional cues in social contexts. CONCLUSIONS: The study highlights how atypical neural adaptation in autism how emotional content impacts social communication deficits. These insights enhance understanding of autism-related adaptation challenges.
Filiaciones:
Merchie A:
Université de Tours, INSERM, Imaging Brain and Neuropsychiatry iBraiN U1253, 37032, Tours, France
EXAC·T, Centre Universitaire de Pédopsychiatrie, CHRU de Tours, Tours, France
Bonnet-Brilhault F:
Université de Tours, INSERM, Imaging Brain and Neuropsychiatry iBraiN U1253, 37032, Tours, France
EXAC·T, Centre Universitaire de Pédopsychiatrie, CHRU de Tours, Tours, France
Centre Ressource Autisme région Centre-Val de Loire, CHRU de Tours, Tours, France
Escera C:
Neuroscience Research Group, Department of Clinical Psychology and Psychobiology, Brainlab - Cognitive, University of Barcelona, Catalonia, Spain
Institute of Neurosciences, University of Barcelona, Catalonia, Spain
Institut de Recerca Sant Joan de Déu, Santa Rosa 39-57, 08950, Esplugues de Llobregat, Catalonia, Spain
Houy-Durand E:
Université de Tours, INSERM, Imaging Brain and Neuropsychiatry iBraiN U1253, 37032, Tours, France
EXAC·T, Centre Universitaire de Pédopsychiatrie, CHRU de Tours, Tours, France
Centre Ressource Autisme région Centre-Val de Loire, CHRU de Tours, Tours, France
Gomot M:
Université de Tours, INSERM, Imaging Brain and Neuropsychiatry iBraiN U1253, 37032, Tours, France
EXAC·T, Centre Universitaire de Pédopsychiatrie, CHRU de Tours, Tours, France
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