Immune-inflammatory effects of the multicomponent intervention FIBROWALK in outdoor and online formats for patients with fibromyalgia
Por:
Ferrés S, Serrat M, Auer W, Royuela-Colomer E, Almirall M, Lizama-Lefno A, Nijs J, Maes M, Luciano JV, Borràs X and Feliu A
Publicada:
1 mar 2025
Ahead of Print:
1 ene 2025
Resumen:
The multicomponent intervention FIBROWALK integrates pain science education (PSE), therapeutic exercise, cognitive behavioral therapy (CBT), and mindfulness training for treating fibromyalgia (FM). This study investigated the effects of the FIBROWALK in online (FIBRO-On) and outdoor (FIBRO-Out) formats compared to treatment-as-usual (TAU) on core clinical variables along with serum immune-inflammatory biomarkers and brain-derived neurotrophic factor (BDNF). Furthermore, the predictive value of these biomarkers on clinical response to FIBROWALK was also evaluated. 120 participants were randomly divided into three groups: TAU, TAU + FIBRO-On or TAU + FIBRO-Out. Clinical and blood assessments were conducted pre-post treatment. Both FIBRO-Out and FIBRO-On showed effectiveness (vs TAU) by improving functional impairment and kinesiophobia. Individuals allocated to FIBRO-Out (vs TAU) additionally showed decreases in pain, fatigue, depressive symptoms, and serum IL-6 and IL-10 levels along with IL-6/IL-4 ratio; patients allocated to FIBRO-On only showed a less stepped increase in IL-6 compared to TAU. An exaggerated pro-inflammatory profile along with higher levels of BDNF at baseline predicted greater clinical improvements in both active treatment arms. Our results suggest that FIBROWALK -in online and outdoor formats- is effective in individuals with FM and has significant immune regulatory effects in FM patients, while immune-inflammatory pathways and BDNF levels may in part predict its clinical effectiveness. Trial registration number NCT05377567 (clinicaltrials.gov).
Filiaciones:
Ferrés S:
Escoles Universitàries Gimbernat, Autonomous University of Barcelona, Bellaterra, Spain
Department of Basic, Developmental and Educational Psychology, Faculty of Psychology, Autonomous University of Barcelona, Bellaterra, Spain
Serrat M:
Unitat d'Expertesa en Síndromes de Sensibilització Central, Servei de Reumatologia, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain
Auer W:
Department of Basic, Developmental and Educational Psychology, Faculty of Psychology, Autonomous University of Barcelona, Bellaterra, Spain
Royuela-Colomer E:
Department of Clinical and Health Psychology, Faculty of Psychology, Autonomous University of Barcelona, Bellaterra, Spain
Almirall M:
Unitat d'Expertesa en Síndromes de Sensibilització Central, Servei de Reumatologia, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain
Lizama-Lefno A:
Department of Development and Postgraduate, Autonomous University of Chile, Chile
Nijs J:
Pain in Motion Research Group (PAIN), Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium
Department of Health and Rehabilitation, Unit of Physiotherapy, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden
Chronic Pain Rehabilitation, Department of Physical Medicine and Physiotherapy, University Hospital Brussels, Belgium
Maes M:
Sichuan Provincial Center for Mental Health, University of Electronic Science and Technology of China, Chengdu, China
Luciano JV:
Department of Clinical and Health Psychology, Faculty of Psychology, Autonomous University of Barcelona, Bellaterra, Spain
Teaching, Research & Innovation Unit, Parc Sanitari Sant Joan de Déu, St. Boi de Llobregat, Spain
Centre for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
Borràs X:
Department of Basic, Developmental and Educational Psychology, Faculty of Psychology, Autonomous University of Barcelona, Bellaterra, Spain
Centre for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
Feliu A:
Department of Clinical and Health Psychology, Faculty of Psychology, Autonomous University of Barcelona, Bellaterra, Spain
Centre for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
Green Submitted, hybrid
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