Direct ink writing of biomimetic hydroxyapatite scaffolds with tailored concave porosity
Por:
del Mazo-Barbara L, Díez Escudero A, Lodoso-Torrecilla I, Aramesh, Morteza, Persson, Cecilia and Ginebra MP
Publicada:
1 ene 2024
Aceptada:
19 jul 2024
Resumen:
Direct ink writing (DIW) is a promising technology for the fabrication of personalized bone grafts, as it enables the customization of their geometrical conformation with high reproducibility and is compatible with the use of self-setting calcium-deficient hydroxyapatite inks. However, the scaffolds obtained by DIW consist mostly of convex filaments, which is a limitation since concave surfaces are known to promote bone regeneration in vivo. In this work, we explore the use of triply periodic minimal surface (TPMS) designs in DIW of calcium phosphate self-hardening inks as a strategy to obtain scaffolds with controlled concave macropores. The limitations of the printing parameters with high ceramic-loaded inks using DIW resulted in only 20% nominal porosity for gyroid-, diamond-, and Schwarz-based structures. The inherent layered pores from TPMS geometries enabled concavities typically unattainable via DIW, bearing substantial implications for subsequent osteoinductive capabilities. Although the mechanical properties were lower in the TPMS-based scaffolds than in the orthogonal patterned ones, the blood permeability of TPMS-based structures was higher. The concave pore architecture enhanced the osteogenic potential of the and mineralization.
Filiaciones:
Univ Politecn Cataluna, Dept Mat Sci & Engn, Biomat Biomech & Tissue
Engn Grp, Barcelona, Spain
Univ Politecn Cataluna, Res Ctr Biomed Engn, Barcelona, Spain
Univ Politecn Cataluna, Barcelona Res Ctr Multiscale Sci & Engn,
Barcelona, Spain
Inst Recerca St Joan de Deu, Barcelona, Spain
Ctr Invest Biomed Red Bioingn Biomed & Nanomed CIB, Carlos III Hlth
Inst, Madrid, Spain
Uppsala Univ, Dept Mat Sci & Engn, Div Biomed Engn, UPPSALA, Sweden
Uppsala Univ, Addit Mfg Life Sci Competence Ctr AM4Life, Uppsala, Sweden
Barcelona Inst Sci & Technol, Inst Bioengn Catalonia IBEC, Barcelona,
Spain
Green Accepted, Green Submitted, gold
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