Are delusions and/or referentiality associated with aberrant reward prediction error (RPE) signaling? Evidence from fMRI using a probabilistic monetary reward task.
Por:
García-León MÁ, Fuentes-Claramonte P, Gee A, Ramiro-Sousa N, Soler-Vidal J, Salgado-Pineda P, Torres L, Jaurrieta N, Sánchez-Pérez M, Panicali F, Inarejos E, Raduà J, Sarró S, Salvador R, McKenna PJ and Pomarol-Clotet E
Publicada:
20 feb 2025
Ahead of Print:
20 feb 2025
Resumen:
BACKGROUND: According to the aberrant salience proposal, reward processing abnormality, specifically erroneous reward prediction error (RPE) signaling due to stimulus-independent release of dopamine, underlies delusions in schizophrenia. However, no studies to date have examined RPE-associated brain activations in relation to this symptom. METHODS: Seventy-eight patients with a DSM-5 diagnosis of schizophrenia/schizoaffective disorder and 43 healthy individuals underwent fMRI while they performed a probabilistic monetary reward task designed to generate a measure of RPE. Ratings of delusions and referentiality were made in the patients. RESULTS: Using whole-brain, voxel-based analysis, schizophrenia patients showed only minor differences in RPE-associated activation compared to healthy controls. Within the patient group, however, severity of delusions was inversely associated with RPE-associated activation in areas including the caudate nucleus, the thalamus and the left pallidum, as well as the lateral frontal cortex bilaterally, the pre- and postcentral gyrus and supplementary motor area, the middle cingulate gyrus, and parts of the temporal and parietal cortex. A broadly similar pattern of association was seen for referentiality. CONCLUSIONS: According to this study, while patients with schizophrenia as a group do not show marked alterations in RPE signaling, delusions and referentiality are associated with reduced activation in parts of the prefrontal cortex and the basal ganglia, though not specifically the ventral striatum. The direction of the changes is on the face of it contrary to that predicted by aberrant salience theory.
Filiaciones:
García-León MÁ:
Department of Personality, Assessment, and Psychological Treatments, Universidad de Sevilla, Seville, Spain
Fuentes-Claramonte P:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Instituto de Salud Carlos III, Barcelona, Spain
Gee A:
Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK
University of Cambridge, Cambridge, UK
Ramiro-Sousa N:
Fundació Hospitalàries Barcelona - Hospital General, Barcelona, Spain
Soler-Vidal J:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Instituto de Salud Carlos III, Barcelona, Spain
Fundació Hospitalàries Sant Boi, Sant Boi de Llobregat, Barcelona, Spain
Universitat Autònoma de Barcelona, Barcelona, Spain
Salgado-Pineda P:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Instituto de Salud Carlos III, Barcelona, Spain
Torres L:
Fundació Hospitalàries Barcelona, Barcelona, Spain
Jaurrieta N:
Fundació Hospitàries Martorell, Martorell, Barcelona, Spain
Sánchez-Pérez M:
Fundació Hospitàries Martorell, Martorell, Barcelona, Spain
Universitat Autònoma de Barcelona, Barcelona, Spain
Panicali F:
Fundació Hospitalàries Sant Boi, Sant Boi de Llobregat, Barcelona, Spain
Inarejos E:
Departament de diagnòstic per la Imatge, Hospital Sant Joan de Déu, Barcelona, Spain
Raduà J:
CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Instituto de Salud Carlos III, Barcelona, Spain
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
University of Barcelona, Barcelona, Spain
Sarró S:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Instituto de Salud Carlos III, Barcelona, Spain
Salvador R:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Instituto de Salud Carlos III, Barcelona, Spain
McKenna PJ:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Instituto de Salud Carlos III, Barcelona, Spain
Pomarol-Clotet E:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Instituto de Salud Carlos III, Barcelona, Spain
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