Epigenome-wide association study of pregnancy exposure to green space and placental DNA methylation.
Por:
Aguilar-Lacasaña S, Cosin-Tomas M, Raimbault B, Gómez-Herrera L, Sánchez O, Zanini MJ, Pascal-Capdevila R, Foraster M, Gascon M, Rivas I, Llurba E, Gómez-Roig MD, Sunyer J, Bustamante M, Vrijheid M and Dadvand P
Publicada:
1 jun 2025
Ahead of Print:
4 mar 2025
Resumen:
Green space exposure during pregnancy has been associated with lower risk of adverse birth outcomes, but the biological mechanisms remain unclear. Epigenetic changes, such as DNA methylation (DNAm), may contribute to this association. The placenta, crucial for foetal development, has been understudied in relation to prenatal green space exposure and DNAm on a genome-wide scale. Here, we aimed to investigate the association between green space exposure during pregnancy and epigenome-wide placental DNAm in 550 mother-child pairs from the Barcelona Life Study Cohort (BiSC) in Spain. Green space exposure was assessed as (i) residential surrounding greenness (satellite-based Normalized Difference Vegetation Index (NDVI) in buffers of 100 m, 300 m and 500 m), (ii) residential distance to the nearest major green space (meters), (iii) use of green space (hours/week), and (iv) visual access to greenery through the home window (=half of the view). Placental DNAm was measured with the EPIC array. Differentially methylated positions (DMPs) were identified using robust linear regression models adjusted for covariates, while differentially methylated regions (DMRs) were identified using the dmrff method. After Bonferroni correction, cg14852540, annotated to SLC25A10 gene, showed an inverse association with residential greenness within 500 m buffer. Additionally, 101 DMPs were suggestively significant (p-values <1 × 10(-5)) and annotated to genes involved in glucocorticoid-related pathways, inflammatory response, oxidative stress response, and oocyte maturation. No DMRs were identified. Overall, we identified an association between residential greenness and DNAm levels at one CpG in the SLC25A10 gene. Larger studies are needed to validate these findings and understand the biological pathways.
Filiaciones:
Aguilar-Lacasaña S:
ISGlobal, Barcelona, Spain
Universitat de Barcelona (UB), Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
CIBER Epidemiología y Salud Pública, Instituto de Salud Carlos III, Spain
Cosin-Tomas M:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
CIBER Epidemiología y Salud Pública, Instituto de Salud Carlos III, Spain
Raimbault B:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
CIBER Epidemiología y Salud Pública, Instituto de Salud Carlos III, Spain
Gómez-Herrera L:
ISGlobal, Barcelona, Spain
Universitat de Barcelona (UB), Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
CIBER Epidemiología y Salud Pública, Instituto de Salud Carlos III, Spain
Sánchez O:
Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin Network (RICORS-SAMID) (RD21/0012/0001), Spain
Department of Obstetrics and Gynaecology. Hospital de la Santa Creu i Sant Pau, Institut de Recerca (IR SANT PAU), Barcelona, 08041, Spain
Zanini MJ:
Department of Obstetrics and Gynaecology. Hospital de la Santa Creu i Sant Pau, Institut de Recerca (IR SANT PAU), Barcelona, 08041, Spain
Pascal-Capdevila R:
Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin Network (RICORS-SAMID) (RD21/0012/0003), Spain
BCNatal. Barcelona Center for Maternal Foetal and Neonatal Medicine (Hospital Sant Joan de Déu and Hospital Clínic), University of Barcelona, Barcelona, Spain
Foraster M:
PHAGEX Research Group, Blanquerna School of Health Science, Universitat Ramon Llull (URL), Barcelona, Spain
Gascon M:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
CIBER Epidemiología y Salud Pública, Instituto de Salud Carlos III, Spain
Unitat de Suport a la Recerca de la Catalunya Central, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Manresa, Spain
Rivas I:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
CIBER Epidemiología y Salud Pública, Instituto de Salud Carlos III, Spain
Llurba E:
Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin Network (RICORS-SAMID) (RD21/0012/0001), Spain
Department of Obstetrics and Gynaecology. Hospital de la Santa Creu i Sant Pau, Institut de Recerca (IR SANT PAU), Barcelona, 08041, Spain
Gómez-Roig MD:
Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin Network (RICORS-SAMID) (RD21/0012/0003), Spain
BCNatal. Barcelona Center for Maternal Foetal and Neonatal Medicine (Hospital Sant Joan de Déu and Hospital Clínic), University of Barcelona, Barcelona, Spain
Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain
Sunyer J:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
CIBER Epidemiología y Salud Pública, Instituto de Salud Carlos III, Spain
Bustamante M:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
CIBER Epidemiología y Salud Pública, Instituto de Salud Carlos III, Spain
Vrijheid M:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
CIBER Epidemiología y Salud Pública, Instituto de Salud Carlos III, Spain
Dadvand P:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
CIBER Epidemiología y Salud Pública, Instituto de Salud Carlos III, Spain
Green Accepted
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