The Usefulness of High-Frequency Ultrasound in the Management of Patients With Giant Congenital Melanocytic Nevi: A Cohort Prospective Study.
Por:
Giavedoni P, Fallas S, Serra L, Torres T, Rosés-Gibert P, de Vega IF, Vicente-Villa MA, Wortsman X and Carrera C
Publicada:
1 jul 2025
Ahead of Print:
20 mar 2025
Resumen:
OBJECTIVES: Congenital melanocytic nevi (CMN) exhibit various clinical presentations. Dermoscopy and confocal microscopy only assess the superficial dermis. Magnetic resonance imaging cannot evaluate skin layers comprehensively. High-frequency Doppler ultrasound (HFUS) can define the extent of melanocytic lesions and suggest patterns of potential complications. The objective of the study is to evaluate HFUS characteristics of patients with CMN and, secondarily, to study the utility of HFUS in evaluating proliferative nodules and enlarged lymph nodes. METHODS: A prospective study of patients with multiple and non-small CMN between January 2016 and June 2021 was conducted. Clinical imaging and HFUS were routinely used to follow up on distinctive areas. A retrospective analysis of HFUS images and correlation with presentation was performed. RESULTS: Seventy-one patients with CMN, 149 HFUS scans. Median age: 14 years (IQR: 8 months-79 years), 59% female. Large/giant nevi n = 44 (61.9%). CMN affected the epidermis/dermis in 51 (71.8%), hypodermis in 17 (24%), and muscle in 3 (4.2%). Thirteen patients (18.3%) had nodular lesions; 1 showed atypical vessels on HFUS, which was confirmed histologically as an atypical proliferative nodule. LIMITATIONS: Heterogeneity of patients and retrospective analysis. CONCLUSIONS: HFUS allows the characterization of non-small CMN by assessing depth and diagnosing complications such as melanomas and enlarged lymph nodes.
Filiaciones:
Giavedoni P:
Dermatology Department, Hospital Clínic, University of Barcelona, Barcelona, Spain
Melanoma Group IDIBAPS and CIBERER, Instituto de Salud Carlos III, Madrid, Spain
Fallas S:
Dermatology Department, Hospital Clínic, University of Barcelona, Barcelona, Spain
Serra L:
Dermatology Department, Hospital Clínic, University of Barcelona, Barcelona, Spain
Torres T:
Melanoma Group IDIBAPS and CIBERER, Instituto de Salud Carlos III, Madrid, Spain
Rosés-Gibert P:
Dermatology Department, Hospital Clínic, University of Barcelona, Barcelona, Spain
de Vega IF:
Dermatology Department, Hospital Clínic, University of Barcelona, Barcelona, Spain
Vicente-Villa MA:
Pediatric Dermatology Department, Hospital Sant Joan de Deu, Barcelona, Spain
Wortsman X:
Department of Dermatology, Universidad de Chile, Santiago, Chile
Department of Dermatology, Pontificia Universidad Católica de Chile, Santiago, Chile
Institute for Diagnostic Imaging and Research of the Skin and Soft Tissues, Santiago, Chile
Carrera C:
Dermatology Department, Hospital Clínic, University of Barcelona, Barcelona, Spain
Melanoma Group IDIBAPS and CIBERER, Instituto de Salud Carlos III, Madrid, Spain
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