Bimetallic Pd/CuO nanoparticles obtained by laser re-irradiation in liquids for antibacterial applications
Por:
Vilas, Ana Maria, Fernández Arias, Mónica, Boutinguiza, Mohamed, Rodríguez, Daniel, Solla, Eugenio, Vilella i, T., del Val, Jesús, Riveiro, A, Gil, Javier and Pou, Juan
Publicada:
1 jun 2025
Ahead of Print:
1 jun 2025
Resumen:
Antimicrobial resistance (AMR) is considered a major global health
problem of the 21st century. Noble metal nanoparticles (NPs) have
attracted increasing attention as a promising tool to fight against
resistant infections. In this research, we explore bimetallic NPs, as
they can give rise to further and improved physicochemical and
biological properties. In this work, monometallic Cu/CuO and Pd NPs were
synthesized by laser ablation. Afterwards, these NPs were mixed and the
resulting colloidal solution was multiply re-irradiated with the aim of
producing Pd/CuO bimetallic NPs. All the NPs presented rounded shape and
crystalline microstructure. Although the re-irradiated NPs contained
both precursor materials, all characterization techniques agreed on the
occurrence of an intermetallic alloy of both materials, Cu3Pd, that is
concluded to be formed as a consequence of the interaction between the
laser beam and the mixture of monometallic NPs. With the objective of
studying antimicrobial activity against Staphylococcus aureus, the CuO
NPs, Pd NPs and Pd/CuO NPs were immobilized on the surface of titanium
discs. Ion release was tracked during the first 24 h and cytotoxicity of
the immobilized NPs was as well tested with HFF-1 human fibroblast cell
line. Bimetallic Pd/CuO NPs showed a significant inhibitory effect on S.
aureus and no toxic impact on fibroblasts.
Filiaciones:
Univ Vigo, CINTECX, LaserOn Res Grp, EEI, Vigo 36310, Spain
SERGAS UVIGO, Galicia Hlth Res Inst IIS Galicia Sur, Vigo 36213, Spain
Univ Politecn Cataluna, Dept Mat Sci & Engn, BBT & CIEFMA Res Grp, Av
Eduard Maristany 10, Barcelona 08019, Spain
Univ Politecn Cataluna, Res Ctr Biomed Engn, Campus Diagonal Besos
EEBE,Av Eduard Maristany 10, Barcelona 08019, Barcelona, Spain
Univ Politecn Cataluna, Barcelona Res Ctr Multiscale Sci & Engn, Campus
Diagonal Besos EEBE, Barcelona 08019, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Bioingn Biomat & Nanomed
CIB, Madrid 28029, Spain
Univ Int Catalunya, Sch Dent, Barcelona 08017, Spain
Open Access
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