Use of procalcitonin in therapeutic decisions in the pediatric intensive care unit.
Por:
Tissières P, Esteban-Torne E, Hübner J, Randolph AG, Rey Galán C and Weiss SL
Publicada:
23 abr 2025
Ahead of Print:
23 abr 2025
Resumen:
Procalcitonin (PCT) is frequently used by clinicians in children with suspected bacterial infections and sepsis. However interpretation in the critically ill child may be challenging due to the complexity of underlying conditions and its impact on PCT values. Herein, we propose a guidance for the use of procalcitonin in critically ill children, supported by a comprehensive analysis of the literature, to help the clinician for interpreting PCT in the various clinical conditions encountered in pediatric intensive care units. We describe the importance of the clinical context, timing of measurement and evidence on PCT values in diagnosing sepsis and to guide antibiotic therapy in critically ill children.
Filiaciones:
Tissières P:
IHU-PROMETHEUS Comprehensive Sepsis Center, Pediatric Intensive Care, Neonatal Medicine and Pediatric Emergency Department, AP-HP Paris Saclay University, Bicêtre Hospital, 78, Rue du General Leclerc, 94275, Le Kremlin-Bicêtre, France
Esteban-Torne E:
University of Barcelona, Hospital Sant Joan de Déu, Barcelona, Spain
Hübner J:
Ludwig-Maximilian-University, Hauner Children's Hospital, Munich, Germany
Randolph AG:
Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA
Rey Galán C:
University of Oviedo, Hospital Universitario Central de Asturias (HUCA), Health Research Institute of the Principality of Asturias (ISPA), Oviedo, Spain
Weiss SL:
Thomas Jefferson University, Nemours Children's Health, Jacksonville, DE, USA
Green Submitted, gold
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