Mapping genomic loci implicates genes and synaptic biology in schizophrenia


Por: Trubetskoy, Vassily, Pardinas, Antonio F., Qi, Ting, Panagiotaropoulou, Georgia, Awasthi, Swapnil, Bigdeli, Tim B., Bryois, Julien, Chen, Chia-Yen, Dennison, Charlotte A., Hall, Lynsey S., Lam, Max, Watanabe, Kyoko, Frei, Oleksandr, Ge, Tian, Harwood, Janet C., Koopmans, Frank, Magnusson, Sigurdur, Richards, Alexander L., Sidorenko, Julia, Wu, Yang, Zeng, Jian, Grove, Jakob, Kim, Minsoo, Li, Zhiqiang, Voloudakis, Georgios, Zhang, Wen, Adams, Mark, Agartz, Ingrid, Atkinson, Elizabeth G., Agerbo, Esben, Al Eissa, Mariam, Albus, Margot, Alexander, Madeline, Alizadeh, Behrooz Z., Alptekin, Koksal, Als, Thomas D., Amin, Farooq, Arolt, Volker, Arrojo, Manuel, Athanasiu, Lavinia, Azevedo, Maria Helena, Bacanu, Silviu A., Bass, Nicholas J., Begemann, Martin, Belliveau, Richard A., Bene, Judit, Benyamin, Beben, Bergen, Sarah E., Blasi, Giuseppe, Bobes, Julio, Bonassi, Stefano, Braun, Alice, Bressan, Rodrigo Affonseca, Bromet, Evelyn J., Bruggeman, Richard, Buckley, Peter F., Buckner, Randy L., Bybjerg-Grauholm, Jonas, Cahn, Wiepke, Cairns, Murray J., Calkins, Monica E., Carr, Vaughan J., Castle, David, Catts, Stanley, V, Chambert, Kimberley D., Chan, Raymond C. K., Chaumette, Boris, Cheng, Wei, Cheung, Eric F. C., Chong, Siow Ann, Cohen, David, Consoli, Angele, Cordeiro, Quirino, Costas, Javier, Curtis, Charles, Davidson, Michael, Davis, Kenneth L., de Haan, Lieuwe, Degenhardt, Franziska, DeLisi, Lynn E., Demontis, Ditte, Dickerson, Faith, Dikeos, Dimitris, Dinan, Timothy, Djurovic, Srdjan, Duan, Jubao, Ducci, Giuseppe, Dudbridge, Frank, Eriksson, Johan G., Fananas, Lourdes, Faraone, Stephen, V, Fiorentino, Alessia, Forstner, Andreas, Frank, Josef, Freimer, Nelson B., Fromer, Menachem, Frustaci, Alessandra, Gadelha, Ary, Genovese, Giulio, Gershon, Elliot S., Giannitelli, Marianna, Giegling, Ina, Giusti-Rodriguez, Paola, Godard, Stephanie, Goldstein, Jacqueline, I, Penas, Javier Gonzalez, Gonzalez-Pinto, Ana, Gopal, Srihari, Gratten, Jacob, Green, Michael F., Greenwood, Tiffany A., Guillin, Olivier, Guloksuz, Sinan, Gur, Raquel E., Gur, Ruben C., Gutierrez, Blanca, Hahn, Eric, Hakonarson, Hakon, Haroutunian, Vahram, Hartmann, Annette M., Harvey, Carol, Hayward, Caroline, Henskens, Frans A., Herms, Stefan, Hoffmann, Per, Howrigan, Daniel P., Ikeda, Masashi, Iyegbe, Conrad, Joa, Inge, Julia, Antonio, Kahler, Anna K., Kam-Thong, Tony, Kamatani, Yoichiro, Karachanak-Yankova, Sena, Kebir, Oussama, Keller, Matthew C., Kelly, Brian J., Khrunin, Andrey, Kim, Sung-Wan, Klovins, Janis, Kondratiev, Nikolay, Konte, Bettina, Kraft, Julia, Kubo, Michiaki, Kucinskas, Vaidutis, Kucinskiene, Zita Ausrele, Kusumawardhani, Agung, A-Ptackova, Hana Kuzelov, Landi, Stefano, Lazzeroni, Laura C., Lee, Phil H., Legge, Sophie E., Lehrer, Douglas S., Lencer, Rebecca, Lerer, Bernard, Li, Miaoxin, Lieberman, Jeffrey, Light, Gregory A., Limborska, Svetlana, Liu, Chih-Min, Lonnqvist, Jouko, Loughland, Carmel M., Lubinski, Jan, Luykx, Jurjen J., Lynham, Amy, Macek, Milan, Jr., Mackinnon, Andrew, Magnusson, Patrik K. E., Maher, Brion S., Maier, Wolfgang, Malaspina, Dolores, Mallet, Jacques, Marder, Stephen R., Marsal, Sara, Martin, Alicia R., Martorell, Lourdes, Mattheisen, Manuel, McCarley, Robert W., McDonald, Colm, McGrath, John J., Medeiros, Helena, Meier, Sandra, Melegh, Bela, Melle, Ingrid, Mesholam-Gately, Raquelle, I, Metspalu, Andres, Michie, Patricia T., Milani, Lili, Milanova, Vihra, Mitjans, Marina, Molden, Espen, Molina, Esther, Molto, Maria Dolores, Mondelli, Valeria, Moreno, Carmen, Morley, Christopher P., Muntane, Gerard, Murphy, Kieran C., Myin-Germeys, Inez, Nenadic, Igor, Nestadt, Gerald, Nikitina-Zake, Liene, Noto, Cristiano, Nuechterlein, Keith H., O'Brien, Niamh Louise, O'Neill, F. Anthony, Oh, Sang-Yun, Olincy, Ann, Ota, Vanessa Kiyomi, Pantelis, Christos, Papadimitriou, George N., Parellada, Mara, Paunio, Tiina, Pellegrino, Renata, Periyasamy, Sathish, Perkins, Diana O., Pfuhlmann, Bruno, Pietilainen, Olli, Pimm, Jonathan, Porteous, David, Powell, John, Quattrone, Diego, Quested, Digby, Radant, Allen D., Rampino, Antonio, Rapaport, Mark H., Rautanen, Anna, Reichenberg, Abraham, Roe, Cheryl, Roffman, Joshua L., Roth, Julian, Rothermundt, Matthias, Rutten, Bart P. F., Saker-Delye, Safaa, Salomaa, Veikko, Sanjuan, Julio, Santoro, Marcos Leite, Savitz, Adam, Schall, Ulrich, Scott, Rodney J., Seidman, Larry J., Sharp, Sally Isabel, Shi, Jianxin, Siever, Larry J., Sigurdsson, Engilbert, Sim, Kang, Skarabis, Nora, Slominsky, Petr, So, Hon-Cheong, Sobell, Janet L., Soderman, Erik, Stain, Helen J., Steen, Nils Eiel, Steixner-Kumar, Agnes A., Stogmann, Elisabeth, Stone, William S., Straub, Richard E., Streit, Fabian, Strengman, Eric, Stroup, T. Scott, Subramaniam, Mythily, Sugar, Catherine A., Suvisaari, Jaana, Svrakic, Dragan M., Swerdlow, Neal R., Szatkiewicz, Jin P., Thi Minh Tam Ta, Takahashi, Atsushi, Terao, Chikashi, Thibaut, Florence, Toncheva, Draga, Tooney, Paul A., Torretta, Silvia, Tosato, Sarah, Tura, Gian Battista, Turetsky, Bruce, I, Ucok, Alp, Vaaler, Arne, van Amelsvoort, Therese, van Winkel, Ruud, Veijola, Juha, Waddington, John, Walter, Henrik, Waterreus, Anna, Webb, Bradley T., Weiser, Mark, Williams, Nigel M., Witt, Stephanie H., Wormley, Brandon K., Wu, Jing Qin, Xu, Zhida, Yolken, Robert, Zai, Clement C., Zhou, Wei, Zhu, Feng, Zimprich, Fritz, Ayub, Muhammad, Benner, Christian, Bertolino, Alessandro, Black, Donald W., Bray, Nicholas J., Breen, Gerome, Buccola, Nancy G., Byerley, William F., Chen, Wei J., Cloninger, C. Robert, Crespo-Facorro, Benedicto, Donohoe, Gary, Freedman, Robert, Galletly, Cherrie, Gandal, Michael J., Gennarelli, Massimo, Hougaard, David M., Hwu, Hai-Gwo, Jablensky, Assen, V, McCarroll, Steven A., Moran, Jennifer L., Mors, Ole, Mortensen, Preben B., Muller-Myhsok, Bertram, Neil, Amanda L., Nordentoft, Merete, Pato, Michele T., Petryshen, Tracey L., Pirinen, Matti, Pulver, Ann E., Schulze, Thomas G., Silverman, Jeremy M., Smoller, Jordan W., Stahl, Eli A., Tsuang, Debby W., Vilella, Elisabet, Wang, Shi-Heng, Xu, Shuhua, Adolfsson, Rolf, Arango, Celso, Baune, Bernhard T., Belangero, Sintia Iole, Borglum, Anders D., Braff, David, Bramon, Elvira, Buxbaum, Joseph D., Campion, Dominique, Cervilla, Jorge A., Cichon, Sven, Collier, David A., Corvin, Aiden, Curtis, David, Di Forti, Marta, Domenici, Enrico, Ehrenreich, Hannelore, Escott-Price, Valentina, Esko, Tonu, Fanous, Ayman H., Gareeva, Anna, Gawlik, Micha, Gejman, Pablo, V, Gill, Michael, Glatt, Stephen J., Golimbet, Vera, Hong, Kyung Sue, Hultman, Christina M., Hyman, Steven E., Iwata, Nakao, Jonsson, Erik G., Kahn, Rene S., Kennedy, James L., Khusnutdinova, Elza, Kirov, George, Knowles, James A., Krebs, Marie-Odile, Laurent-Levinson, Claudine, Lee, Jimmy, Lencz, Todd, Levinson, Douglas F., Li, Qingqin S., Liu, Jianjun, Malhotra, Anil K., Malhotra, Dheeraj, McIntosh, Andrew, McQuillin, Andrew, Menezes, Paulo R., Morgan, Vera A., Morris, Derek W., Mowry, Bryan J., Murray, Robin M., Nimgaonkar, Vishwajit, Nothen, Markus M., Ophoff, Roel A., Paciga, Sara A., Palotie, Aarno, Pato, Carlos N., Qin, Shengying, Rietschel, Marcella, Riley, Brien P., Rivera, Margarita, Rujescu, Dan, Saka, Meram C., Sanders, Alan R., Schwab, Sibylle G., Serretti, Alessandro, Sham, Pak C., Shi, Yongyong, St Clair, David, Stefansson, Hreinn, Stefansson, Kari, Tsuang, Ming T., van Os, Jim, Vawter, Marquis P., Weinberger, Daniel R., Werge, Thomas, Wildenauer, Dieter B., Yu, Xin, Yue, Weihua, Holmans, Peter A., Pocklington, Andrew J., Roussos, Panos, Vassos, Evangelos, Verhage, Matthijs, Visscher, Peter M., Yang, Jian, Posthuma, Danielle, Andreassen, Ole A., Kendler, Kenneth S., Owen, Michael J., Wray, Naomi R., Daly, Mark J., Huang, Hailiang, Neale, Benjamin M., Sullivan, Patrick F., Ripke, Stephan, Walters, James T. R. and O'Donovan, Michael C.

Publicada: 21 abr 2022 Ahead of Print: 1 abr 2022
Categoría: Multidisciplinary

Resumen:
Schizophrenia has a heritability of 60-80%(1), much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factorSP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies.

Filiaciones:
Inst Mental Hlth, Res Div, Singapore, Singapore
Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
Vrije Univ Amsterdam, Ctr Neurogen & Cognit Res, Amsterdam Neurosci,
Dept Complex Trait Genet, Amsterdam, Netherlands
Univ Oslo, NORMENT Ctr, Div Mental Hlth & Addict, Oslo, Norway
Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway
Univ Oslo, Ctr Bioinformat, Dept Informat, Oslo, Norway
Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA
Vrije Univ, Fac Sci, Ctr Neurogen & Cognit Res, Dept Mol & Cellular
Neurobiol,Amsterdam Neurosci, Amsterdam, Netherlands
Amgen Inc, DeCODE Genet, Reykjavik, Iceland
Lundbeck Fdn Initiat Integrat Psychiat Res iPSYCH, Aarhus, Denmark
Aarhus Univ, Dept Biomed, Aarhus, Denmark
Aarhus Univ, Ctr Integrat Sequencing iSEQ, Aarhus, Denmark
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Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst, Dept Psychiat,
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Qingdao Univ, Affiliated Hosp, Qingdao, Peoples R China
Qingdao Univ, SJTU Bio X Inst, Qingdao Branch, Biomed Sci Inst, Qingdao,
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Shanghai Jiao Tong Univ, Collaborat Innovat Ctr Brain Sci, Bio X
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Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA
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Univ Edinburgh, Royal Edinburgh Hosp, Ctr Clin Brain Sci, Div Psychiat,
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Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway
Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden
Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Cambridge, MA 02142
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Massachusetts Gen Hosp, Ctr Genom Med, Psychiat & Neurodev Genet Unit,
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Biogen Inc, 14 Cambridge Ctr, Cambridge, MA 02142 USA
Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
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Vet Affairs New York Harbor Healthcare Syst, Dept Psychiat, New York, NY
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Stockholm Hlth Care Serv, Stockholm, Sweden
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IRCCS San Raffaele Roma, Unit Clin & Mol Epidemiol, Rome, Italy
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2nd Fac Med, Dept Biol & Med Genet, Prague, Czech Republic
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Univ New South Wales, Black Dog Inst, Randwick, NSW, Australia
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Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mental Hlth,
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Hop Univ La Pitie Salpetriere, iPEPS ICM, Asfalia Biol, Paris, France
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Diakonhjemmet Hosp, Ctr Psychopharmacol, Oslo, Norway
Univ Granada, Fac Hlth Sci, Dept Nursing, Granada, Spain
Univ Valencia, Fac Biol Sci, Dept Genet, Valencia, Spain
Biomed Res Inst Incl, Valencia, Spain
Kings Coll London, Inst Psychiat, Dept Psychol Med, London, England
State Univ New York, Upstate Med Univ, Dept Publ Hlth Psychiat & Behav
Sci, Syracuse, NY USA
Univ Pompeu Fabra, Inst Biol Evolut UPF CSIC, Dept Ciencies Expt &
Salut, PRBB, Barcelona, Spain
Royal Coll Surgeons Ireland, Dept Psychiat, Dublin, Ireland
Katholieke Univ Leuven, Dept Neurosci, Ctr Contextual Psychiat, Leuven,
Belgium
Philipps Univ Marburg, Dept Psychiat & Psychotherapy, Cognit
Neuropsychiat Lab, Marburg, Germany
Jena Univ Hosp, Dept Psychiat & Psychotherapy, Jena, Germany
Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD
21205 USA
Queens Univ Belfast, Ctr Publ Hlth, Inst Clin Sci, Belfast, Antrim,
North Ireland
Univ Calif Santa Barbara, Dept Stat & Appl Probabil, Santa Barbara, CA
93106 USA
Lawrence Berkeley Natl Lab, Computat Res Div, Berkeley, CA USA
Univ Colorado Denver, Dept Psychiat, Aurora, CO USA
Univ Fed Sao Paulo, Dept Morphol & Genet, Lab Genet, Sao Paulo, Brazil
Univ Melbourne, Melbourne Neuropsychiat Ctr, Melbourne, Vic, Australia
Melbourne Hlth, Melbourne, Vic, Australia
Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic,
Univ Melbourne, Melbourne Med Sch, Dept Psychiat, Parkville, Vic,
Natl Inst Hlth & Welf, Dept Publ Hlth Solut, Genom & Biomarkers Unit,
Helsinki, Finland
Univ Helsinki, Fac Med, Dept Psychiat, Helsinki, Finland
Univ Helsinki, Fac Med, SleepWell Res Program, Helsinki, Finland
Univ Queensland, Queensland Ctr Mental Hlth Res, Brisbane, Qld,
Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA
Weisser Hirsch, Clin Psychiat & Psychotherapy, Dresden, Germany
Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA
Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland
Univ Edinburgh, Western Gen Hosp, Ctr Genom & Expt Med, Inst Genet & Mol
Med, Edinburgh, Midlothian, Scotland
Kings Coll London, Inst Psychiat, Dept Basic & Clin Neurosci, London,
South London & Maudsley NHS Mental Hlth Fdn Trust, London, England
Warneford Hosp, Oxford Hlth NHS Fdn Trust, Oxford, England
Univ Oxford, Dept Psychiat, Oxford, England
Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA USA
VA Puget Sound Hlth Care Syst, Seattle, WA USA
Univ Utah, Sch Med, Dept Psychiat, Huntsman Mental Hlth Inst, Salt Lake
City, UT 84112 USA
SUNY Upstate Med Univ, Syracuse, NY 13210 USA
Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA
Julius Maximilians Univ Wurzburg, Dept Psychiat Psychosomat &
Psychotherapy, Wurzburg, Germany
Généthon, Evry, France
THL Finnish Inst Hlth & Welf, Helsinki, Finland
Univ Valencia, Hosp Clin Univ Valencia, Sch Med, Dept Psychiat,
Valencia, Spain
Univ Newcastle, Mater Hosp, Prior Ctr Brain & Mental Hlth Res, McAuley
Ctr, Newcastle, NSW, Australia
NSW Hlth Pathol North, Div Mol Med, Newcastle, NSW, Australia
NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
James J Peters VA Med Ctr, Bronx, NY USA
Univ Iceland, Fac Med, Reykjavik, Iceland
Landspitali Univ Hosp, Dept Psychiat, Reykjavik, Iceland
Inst Mental Hlth, Singapore, Singapore
Natl Univ Singapore, Yoo Loo Lin Sch Med, Singapore, Singapore
Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore
Chinese Univ Hong Kong, Sch Biomed Sci, Hong Kong, Peoples R China
Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Peoples R China
Leeds Trinity Univ, Sch Social & Hlth Sci, Leeds, W Yorkshire, England
Stavanger Univ Hosp, TIPS Network Clin Res Psychosis, Stavanger, Norway
Univ Oslo, NORMENT Ctr, Inst Clin Med, Oslo, Norway
Med Univ Vienna, Dept Neurol, Vienna, Austria
Harvard Med Sch, Dept Psychiat, Beth Israel Deaconess Med Ctr, Boston,
MA 02115 USA
Massachusetts Mental Hlth Ctr, Boston, MA 02115 USA
Lieber Inst Brain Dev, Baltimore, MD USA
Univ Med Ctr Utrecht, Dept Med Genet, Utrecht, Netherlands
Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Biostat, Los
Washington Univ, Dept Psychiat, St Louis, MO USA
Charite Univ Med Berlin, Dept Psychiat, Berlin, Germany
Berlin Inst Hlth BIH, Berlin, Germany
RIKEN Ctr Integrat Med Sci, Lab Stat & Translat Genet, Yokohama,
Kanagawa, Japan
Univ Paris, Fac Med, Hop Cochin Tarnier, Paris, France
Inst Psychiat & Neurosci, INSERM U1266, Paris, France
Bulgarian Acad Sci, Sofia, Bulgaria
Univ Verona, Dept Neurosci Biomed & Movement Sci, Sect Psychiat, Verona,
IRCCS Ist Ctr San Giovanni di Dio Fatebenefratel, Psychiat Unit,
Brescia, Italy
Istanbul Univ, Fac Med, Dept Psychiat, Istanbul, Turkey
Trondheim Reg & Univ Hosp, Div Mental Hlth, St Olavs Hosp, Trondheim,
Norway
Norwegian Univ Sci & Technol, Dept Mental Hlth, Trondheim, Norway
Katholieke Univ Leuven, Dept Neurosci, Ctr Clin Psychiat, Leuven,
Univ Oulu, Dept Psychiat, Res Unit Clin Neurosci, Oulu, Finland
Oulu Univ Hosp, Med Res Ctr Oulu, Oulu, Finland
Univ Oulu, Oulu, Finland
Royal Coll Surgeons Ireland, Mol & Cellular Therapeut, Dublin, Ireland
Univ Western Australia, Sch Populat & Global Hlth, Neuropsychiat
Epidemiol Res Unit, Perth, WA, Australia
Univ Western Australia, Ctr Clin Res Neuropsychiat, Perth, WA, Australia
Sheba Med Ctr, Tel Hashomer, Israel
Baker Heart & Diabet Inst, Victoria, Australia
GGz Cent, Dept Psychiat, Utrecht, Netherlands
Johns Hopkins Univ, Sch Med, Stanley Neurovirol Lab, Baltimore, MD USA
Ctr Addict & Mental Hlth, Campbell Family Mental Hlth Res Inst, Toronto,
ON, Canada
Univ Toronto, Dept Psychiat, Toronto, ON, Canada
Xi An Jiao Tong Univ, Dept Psychiat, Affiliated Hosp 1, Xian, Peoples R
Xi An Jiao Tong Univ, Ctr Translat Med, Affiliated Hosp 1, Xian, Peoples
R China
Ankara Univ, Sch Med, Dept Psychiat, Ankara, Turkey
Queens Univ Kingston, Dept Psychiat, Kingston, ON, Canada
Univ Iowa, Dept Psychiat, Carver Coll Med, Iowa City, IA 52242 USA
Louisiana State Univ, Sch Nursing, Hlth Sci Ctr, New Orleans, LA USA
Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA
Ctr Neuropsychiat Res, Natl Hlth Res Inst, Zhunan Town, Taiwan
Natl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol & Prevent Med, Taipei,
Taiwan
Univ Seville, CIBERSAM IBiS, Seville, Spain
Univ Seville, Hosp Univ Virgen del Rocio, Dept Psychiat, Seville, Spain
Univ Adelaide, Adelaide Med Sch, Discipline Psychiat, Adelaide, SA,
Ramsay Hlth Care SA Mental Hlth, Adelaide, SA, Australia
Northern Adelaide Local Hlth Network, Adelaide, SA, Australia
Univ Brescia, Dept Mol & Translat Med, Brescia, Italy
IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, Genet Unit, Brescia,
Natl Taiwan Univ, Coll Med, Dept Psychiat, Taipei, Taiwan
Natl Taiwan Univ, Natl Taiwan Univ Hosp, Taipei, Taiwan
Aarhus Univ Hosp, Psychosis Res Unit, Aarhus, Denmark
Max Planck Inst Psychiat, Munich, Germany
Munich Cluster Syst Neurol, Munich, Germany
Univ Liverpool, Dept Hlth Data Sci, Liverpool, Merseyside, England
Univ Tasmania, Menzies Inst Med Res, Hobart, Tas, Australia
Univ Copenhagen, Mental Hlth Ctr Copenhagen, Mental Hlth Serv Capital
Reg Denmark, Copenhagen, Denmark
Rutgers State Univ, Robert Wood Johnson Med Sch, New Brunswick, NJ USA
Rutgers State Univ, New Jersey Med Sch, Newark, NJ USA
Univ Helsinki, Dept Math & Stat, Helsinki, Finland
Univ Helsinki, Dept Publ Hlth, Helsinki, Finland
SUNY Upstate Med Univ, Dept Psychiat & Behav Sci, Syracuse, NY 13210 USA
Univ Med Ctr Gottingen, Dept Psychiat & Psychotherapy, Gottingen,
Johns Hopkins Univ, Dept Psychiat & Behav Sci, Baltimore, MD USA
Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA
02142 USA
Regeneron Genet Ctr, Orange, CA USA
China Med Univ, Coll Publ Hlth, Taichung, Taiwan
Fudan Univ, Collaborat Innovat Ctr Genet & Dev, Sch Life Sci, Human
Phenome Inst, Shanghai, Peoples R China
ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming, Yunnan,
Umea Univ, Dept Clin Sci, Psychiat, Umea, Sweden
UCL, Dept Mental Hlth Neurosci, Div Psychiat, London, England
Univ Granada, San Cecilio Univ Hosp, Dept Psychiat, Granada, Spain
Univ Hosp Basel, Inst Med Genet & Pathol, Basel, Switzerland
Univ Basel, Dept Biomed, Basel, Switzerland
Res Ctr Juelich, Inst Neurosci & Med INM 1, Julich, Germany
Eli Lilly & Co, Windlesham, Surrey, England
Trinity Coll Dublin, Dept Psychiat, Neuropsychiat Genet Res Grp, Dublin,
UCL, UCL Genet Inst, London, England
Queen Mary Univ London, Ctr Psychiat, London, England
Univ Trento, Dept Cellular Computat & Integrat Biol, Trento, Italy
Cardiff Univ, Dementia Res Inst, Cardiff, Wales
Phoenix VA Healthcare Syst, Dept Psychiat, Phoenix, AZ USA
Banner Univ Med Ctr, Phoenix, AZ USA
Russian Acad Sci IBG UFRC RAS, Ufa Fed Res Ctr, Inst Biochem & Genet,
Dept Human Mol Genet, Ufa, Russia
Bashkir State Med Univ Publ Hlth, Minist Russian Federat BSMU, Fed State
Educ Inst Highest Educ, Ufa, Russia
SUNY Upstate Med Univ, Dept Psychiat & Behav Sci, Psychiat Genet
Epidemiol & Neurobiol Lab PsychGEN, Syracuse, NY USA
Sungkyunkwan Univ, Samsung Med Ctr, Dept Psychiat, Sch Med, Seoul, South
Korea
Univ Southern Calif, Dept Psychiat, Keck Sch Med, Los Angeles, CA USA
Univ Southern Calif, Keck Sch Med, Zilkha Neurogenet Inst, Los Angeles,
CA USA
State Univ New York, Downstate Hlth Sci Univ, Dept Cell Biol, New York,
NY USA
Inst Mental Hlth, Dept Psychosis, Singapore, Singapore
Nanyang Technol Univ, Lee Kong Chian Sch Med, Neurosci & Mental Hlth,
Inst Behav Sci, Feinstein Inst Med Res, Manhasset, NY USA
Zucker Sch Med Hofstra Northwell, Dept Psychiat, Hempstead, NY USA
ASTAR, Genome Inst Singapore, Human Genet, Singapore, Singapore
Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore,
Singapore
F Hoffmann La Roche & Cie AG, Roche Innovat Ctr Basel, Roche Pharma Res
& Early Dev, Basel, Switzerland
Univ Sao Paulo, Fac Med FMUSP, Dept Preventat Med, Sao Paulo, Brazil
Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA
Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Ctr
Neurobehav Genet, Los Angeles, CA 90024 USA
Erasmus MC, Dept Psychiat, Rotterdam, Netherlands
Pfizer Worldwide Res & Dev, Early Clin Dev, Groton, CT USA
Massachusetts Gen Hosp, Dept Med, Dept Neurol, Analyt & Translat Genet
Unit, Boston, MA 02114 USA
Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Shanghai Key Lab
Psychot Disorders, Sch Med, Shanghai, Peoples R China
Univ Granada, Fac Pharm, Dept Biochem & Mol Biol 2, Granada, Spain
Univ Granada, Biomed Res Ctr CIBM, Inst Neurosci, Granada, Spain
Univ Wollongong, Fac Sci, Med & Hlth, Wollongong, NSW, Australia
Illawarra Hlth & Med Res Inst, Wollongong, NSW, Australia
Univ Bologna, Dept Biomed & Neuromotor Sci, Bologna, Italy
Univ Hong Kong, LKS Fac Med, Ctr Panor Sci, Hong Kong, Peoples R China
Univ Hong Kong, LKS Fac Med, State Key Lab Brain & Cognit Sci, Hong
Kong, Peoples R China
Univ Hong Kong, LKS Fac Med, Dept Psychiat, Hong Kong, Peoples R China
Univ Aberdeen, Inst Med Sci, Aberdeen, Scotland
Univ Calif San Diego, Dept Psychiat, Ctr Behav Genom, La Jolla, CA 92093
Univ Calif San Diego, Inst Genom Med, La Jolla, CA 92093 USA
Univ Med Ctr Utrecht, Dept Psychiat, Utrecht, Netherlands
Univ Calif Irvine, Sch Med, Dept Psychiat & Human Behav, Irvine, CA USA
Copenhagen Univ Hosp, Inst Biol Psychiat, Mental Hlth Serv, Copenhagen,
Denmark
Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark
Univ Copenhagen, Ctr GeoGenet, GLOBE Inst, Copenhagen, Denmark
iPSYCH, Lundbeck Fdn Initiat Integrat Psychiat Res, Copenhagen, Denmark
Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA,
Peking Univ Sixth Hosp, Peking Univ Inst Mental Hearth, Beijing, Peoples
Peking Univ, NHC Key Lab Mental Hearth, Natl Clin Res Ctr Mental
Disorders, Beijing, Peoples R China
Chinese Acad Med Sci Res Unit, Beijing, Peoples R China
Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing, Peoples R China
James J Peters VA Med Ctr, Mental Illness Res Educ & Clin Ctr VISN 2
South, New York, NY USA
Oxford Hlth NHS Fdn Trust, Oxford, England
Univ Med Ctr Amsterdam, Ctr Neurogen & Cognit Res, Dept Clin Genet,
Amsterdam, Netherlands
VU Univ Amsterdam & VU Med Ctr, Fac Exact Sci, Ctr Neurogen & Cognit
Res, Dept Funct Genom, Amsterdam, Netherlands
Westlake Lab Life Sci & Biomed, Hangzhou, Peoples R China
ISSN: 00280836





NATURE
Editorial
NATURE PORTFOLIO, HEIDELBERGER PLATZ 3, BERLIN 14197, GERMANY, Reino Unido
Tipo de documento: Article
Volumen: 604 Número: 7906
Páginas: 502-508
WOS Id: 000779867500004
ID de PubMed: 35396580

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