Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.

Por: Strom NI, Gerring ZF, Galimberti M, Yu D, Halvorsen MW, Abdellaoui A, Rodriguez-Fontenla C, Sealock JM, Bigdeli T, Coleman JR, Mahjani B, Thorp JG, Bey K, Burton CL, Luykx JJ, Zai G, Alemany S, Andre C, Askland KD, Bäckman J, Banaj N, Barlassina C, Nissen JB, Bienvenu OJ, Black D, Bloch MH, Børte S, Rosa Bosch Munsó, Breen M, Brennan BP, Brentani H, Buxbaum JD, Bybjerg-Grauholm J, Byrne EM, Cabana-Domínguez J, Camarena B, Camarena A, Cappi C, Carracedo A, Miguel Casas Brugué, Cavallini MC, Ciullo V, Cook EH, Crosby J, Cullen BA, De Schipper EJ, Delorme R, Djurovic S, Elias JA, Estivill X, Falkenstein MJ, Fundin BT, Garner L, Gironda C, Goes FS, Grados MA, Grove J, Guo W, Haavik J, Hagen K, Harrington K, Havdahl A, Höffler KD, Hounie AG, Hucks D, Hultman C, Janecka M, Jenike E, Karlsson EK, Kelley K, Klawohn J, Krasnow JE, Krebs K, Lange C, Lanzagorta N, Levey D, Lindblad-Toh K, Macciardi F, Maher B, Mathes B, McArthur E, McGregor N, McLaughlin NC, Meier S, Miguel EC, Mulhern M, Nestadt PS, Nurmi EL, O'Connell KS, Osiecki L, Ousdal OT, Palviainen T, Pedersen NL, Piras F, Piras F, Potluri S, Rabionet-Janssen R, Ramirez A, Rauch S, Reichenberg A, Riddle MA, Ripke S, Rosário MC, Sampaio AS, Schiele MA, Skogholt AH, Sloofman LG, Smit J, Artigas MS, Thomas LF, Tifft E, Vallada H, van Kirk N, Veenstra-VanderWeele J, Vulink NN, Walker CP, Wang Y, Wendland JR, Winsvold BS, Yao Y, Zhou H, Agrawal A, Alonso P, Berberich G, Bucholz KK, Bulik CM, Cath D, Denys D, Eapen V, Edenberg H, Falkai P, Fernandez TV, Fyer AJ, Gaziano JM, Geller DA, Grabe HJ, Greenberg BD, Hanna GL, Hickie IB, Hougaard DM, Kathmann N, Kennedy J, Lai D, Landén M, Hellard SL, Leboyer M, Lochner C, McCracken JT, Medland SE, Mortensen PB, Neale BM, Nicolini H, Nordentoft M, Pato M, Pato C, Pauls DL, Piacentini J, Pittenger C, Posthuma D, Ramos-Quiroga JA, Rasmussen SA, Richter MA, Rosenberg DR, Ruhrmann S, Samuels JF, Sandin S, Sandor P, Spalletta G, Stein DJ, Stewart SE, Storch EA, Stranger BE, Turiel M, Werge T, Andreassen OA, Børglum AD, Walitza S, Hveem K, Hansen BK, Rück C, Martin NG, Milani L, Mors O, Reichborn-Kjennerud T, Ribasés M, Kvale G, Mataix-Cols D, Domschke K, Grünblatt E, Wagner M, Zwart JA, Breen G, Nestadt G, Kaprio J, Arnold PD, Grice DE, Knowles JA, Ask H, Verweij KJ, Davis LK, Smit DJ, Crowley JJ, Scharf JM, Stein MB, Gelernter J, Mathews CA, Derks EM and Mattheisen M

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Publicada: 1 jun 2025 Ahead of Print: 13 may 2025

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Filiaciones:
Strom NI:
 Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany

 Department of Psychiatric Phenomics and Genomics (IPPG), Ludwig-Maximilians University Munich, Munich, Germany

 Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Services, Region Stockholm, Stockholm, Sweden

 Department of Biomedicine, Aarhus University, Aarhus, Denmark

 University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland

Gerring ZF:
 Department of Mental Health and Neuroscience, Translational Neurogenomics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

 Department of Population Health and Immunity, Healthy Development and Ageing, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia

Galimberti M:
 Department of Psychiatry, Human Genetics, Yale University, New Haven, CT, USA

 VA Connecticut Healthcare System, West Haven, CT, USA

Yu D:
 Department of Center for Genomic Medicine, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA

 Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA

Halvorsen MW:
 Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

Abdellaoui A:
 Department of Psychiatry, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands

Rodriguez-Fontenla C:
 Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Genomics and Bioinformatics, University of Santiago de Compostela, Santiago de Compostela, Spain

 Grupo de Medicina Xenómica, Genetics, Instituto de Investigación Sanitaria de Santiago de Compostela (FIDIS), Santiago de Compostela, Spain

Sealock JM:
 Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA

Bigdeli T:
 Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA

 VA NY Harbor Healthcare System, Brooklyn, NY, USA

Coleman JR:
 Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK

 National Institute for Health and Care Research Maudsley Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK

Mahjani B:
 Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA

 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Thorp JG:
 Mental Health and Neuroscience Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

 Faculty of Medicine, School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia

Bey K:
 Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany

Burton CL:
 Department of Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada

Luykx JJ:
 Department of Psychiatry, Brain University Medical Center Utrecht, Utrecht, the Netherlands

 Second Opinion Outpatient Clinic, GGNet, Warnsveld, the Netherlands

Zai G:
 Molecular Brain Science Department, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada

 Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada

Alemany S:
 Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain

 Department of Mental Health, Hospital Universitari Vall d'Hebron, Barcelona, Spain

 Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain

Andre C:
 Obsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA

Askland KD:
 Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Hamilton, Ontario, Canada

Bäckman J:
 Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Services, Region Stockholm, Stockholm, Sweden

Banaj N:
 Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy

Barlassina C:
 Department of Health Sciences, University of Milano, Milano, Italy

Nissen JB:
 Department of Child and Adolescent Psychiatry, Aarhus University Hospital, Psychiatry, Aarhus, Denmark

 Institute of Clinical Medicine, Health, Aarhus University, Aarhus, Denmark

Bienvenu OJ:
 Department of Psychiatry and Behavioral Sciences, General Hospital Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Black D:
 Departments of Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA

Bloch MH:
 Department of Child Study Center and Psychiatry, Yale University, New Haven, CT, USA

Børte S:
 Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway

 Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology (NTNU), Trondheim, Norway

 Department of Medical Genetics, Oslo University Hospital, Oslo, Norway

Rosa Bosch Munsó:
 Department of Child and Adolescent Mental Health, Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain

 Instituto de Salut Carlos III, Centro de Investigación Biomédica en Red de Salut Mental (CIBERSAM), Madrid, Spain

Breen M:
 Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA

 Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA

 The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

Brennan BP:
 Obsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA

 Department of Psychiatry, Harvard Medical School, Boston, MA, USA

Brentani H:
 Department of Psychiatry, Universidade de São Paulo, São Paulo, Brazil

Buxbaum JD:
 Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA

Bybjerg-Grauholm J:
 Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark

Byrne EM:
 Child Health Research Centre, University of Queensland, Brisbane, Queensland, Australia

Cabana-Domínguez J:
 Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain

 Department of Mental Health, Hospital Universitari Vall d'Hebron, Barcelona, Spain

 Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain

Camarena B:
 Pharmacogenetics Department, Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramon de la Fuente Muñiz, Mexico City, México

Camarena A:
 Department of Surgery, Duke University, Durham, NC, USA

Cappi C:
 Department of Psychiatry, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA

 Department of Psychiatry, University of São Paulo, São Paulo, Brazil

Carracedo A:
 CiMUS, Genomics and Bioinformatics Group, University of Santiago de Compostela, Santiago de Compostela, Spain

 Galician Foundation of Genomic Medicine, Grupo de Medicina Xenómica, Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain

 Medicina Genómica, Centro de Investigación Biomédica en Red, Enfermedades Raras (CIBERER), Santiago de Compostela, Spain

Miguel Casas Brugué:
 Programa MIND Escoles, Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain

 Departamento de Psiquiatría y Medicina Legal, Universitat Autònoma de Barcelona, Bellaterra, Spain

Cavallini MC:
 Department of Psychiatry, Ospedale San Raffaele, Milano, Italy

Ciullo V:
 Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy

Cook EH:
 Department of Psychiatry, University of Illinois Chicago, Chicago, IL, USA

Crosby J:
 Obsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA

 Department of Psychiatry, Harvard Medical School, Boston, MA, USA

Cullen BA:
 Department of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, Baltimore, MD, USA

 Department of Mental Health, Bloomberg School of Public Health, Baltimore, MD, USA

De Schipper EJ:
 Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Services, Region Stockholm, Stockholm, Sweden

Delorme R:
 Child and Adolesccent Psychiatry Department, APHP, Paris, France

Djurovic S:
 Department of Medical Genetics, Oslo University Hospital, Oslo, Norway

 Department of Clinical Science, University of Bergen, Bergen, Norway

Elias JA:
 Psychiatry, McLean Hospital OCDI, Harvard Medical School, Belmont, MA, USA

 Adult Psychological Services, CBTeam LLC, Lexington, MA, USA

Estivill X:
 qGenomics (Quantitative Genomics Laboratories), Esplugues de Llobregat, Spain

Falkenstein MJ:
 Obsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA

 Department of Psychiatry, Harvard Medical School, Boston, MA, USA

Fundin BT:
 Department of Medical Epidemiology and Biostatistics, Center for Eating Disorders Innovation, Karolinska Institutet, Stockholm, Sweden

Garner L:
 Obsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA

Gironda C:
 Obsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA

Goes FS:
 Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA

Grados MA:
 Department of Psychiatry and Behavioral Sciences, Child and Adolescent Psychiatry, Johns Hopkins University, Baltimore, MD, USA

Grove J:
 Department of Biomedicine, Aarhus University, Aarhus, Denmark

 The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark

 Center for Genomics and Personalized Medicine, Aarhus, Denmark

 Bioinformatics Research Centre, Aarhus, Denmark

Guo W:
 Genetic Epidemiology Research Branch, National Institute of Mental Health, Bethesda, MD, USA

Haavik J:
 Department of Biomedicine, University of Bergen, Bergen, Norway

 Bergen Center for Brain Plasticity, Division of Psychiatry, Haukeland University Hospital, Bergen, Norway

Hagen K:
 Department of Psychiatry, Møre og Romsdal Hospital Trust, Molde, Norway

 Bergen Center for Brain Plasticity, Psychiatry, Haukeland University Hospital, Bergen, Norway

 Department of Mental Health, Norwegian University for Science and Technology, Trondheim, Norway

Harrington K:
 Million Veteran Program (MVP) Coordinating Center, VA Boston Healthcare System, Boston, MA, USA

 Department of Psychiatry, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA

Havdahl A:
 PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway

 Nic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway

Höffler KD:
 Department of Clinical Science, University of Bergen, Bergen, Norway

 Bergen Center for Brain Plasticity, Haukeland University Hospital, Bergen, Norway

 Department of Medical Genetics, Dr. Einar Martens Research Group for Biological Psychiatry, Haukeland University Hospital, Bergen, Norway

Hounie AG:
 Department of Psychiatry, University of São Paulo, São Paulo, Brazil

Hucks D:
 Department of Medicine, Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA

Hultman C:
 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Janecka M:
 Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA

 Department of Child and Adolescent Psychiatry, NYU Grossman School of Medicine, New York, NY, USA

Jenike E:
 Obsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA

Karlsson EK:
 Department of Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA, USA

 Department of Vertebrate Genomics, Broad Institute of MIT and Harvard, Cambridge, MA, USA

Kelley K:
 Obsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA

Klawohn J:
 Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany

 Department of Medicine, MSB Medical School Berlin, Berlin, Germany

Krasnow JE:
 Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA

Krebs K:
 Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia

Lange C:
 Department of Biostatistics, T.H. Chan School of Public Health, Boston, MA, USA

 Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA

Lanzagorta N:
 Research Department, Grupo Medico Carracci, Mexico City, Mexico

Levey D:
 Department of Psychiatry, Yale University, West Haven, CT, USA

 Office of Research and Development, United States Department of Veterans Affairs, West Haven, CT, USA

Lindblad-Toh K:
 Department of Vertebrate Genomics, Broad Institute of MIT and Harvard, Cambridge, MA, USA

 Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden

 SciLifeLab, Uppsala University, Uppsala, Sweden

Macciardi F:
 Department of Psychiatry, University of California, Irvine, Irvine, CA, USA

Maher B:
 Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

Mathes B:
 Obsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA

McArthur E:
 Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA

McGregor N:
 COBRE Center for Neuromodulation, Butler Hospital, Providence, RI, USA

McLaughlin NC:
 Department of Psychiatry and Human Behavior, Alpert Medical School, Brown University, Providence, RI, USA

 Butler Hospital, Providence, RI, USA

Meier S:
 Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada

Miguel EC:
 Department of Psychiatry, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil

Mulhern M:
 Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany

Nestadt PS:
 Department of Psychiatry and Behavioral Science, Johns Hopkins University, Baltimore, MD, USA

Nurmi EL:
 Department of Psychiatry and Biobehavioral Sciences, Division of Child and Adolescent Psychiatry, University of California, Los Angeles, Los Angeles, CA, USA

O'Connell KS:
 Department of Clinical Medicine, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway

 NORMENT, University of Oslo, Oslo, Norway

Osiecki L:
 Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA

 Psychiatric and Neurodevelopmental Genetics Unit, Harvard Medical School, Boston, MA, USA

Ousdal OT:
 Department of Biomedicine, University of Bergen, Bergen, Norway

 Department of Biomedicine, Haukeland University Hospital, Bergen, Norway

Palviainen T:
 Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland

Pedersen NL:
 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Piras F:
 Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy

Piras F:
 Department of Clinical Neuroscience and Neurorehabilitation, Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy

Potluri S:
 Obsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA

Rabionet-Janssen R:
 Department of Genetics, Microbiology and Statistics, IBUB, Universitat de Barcelona, Barcelona, Spain

 CIBERER, Centro de Investigación Biomédica en Red, Madrid, Spain

 Department of Human Molecular Genetics, Institut de Recerca Sant Joan de Déu, Barcelona, Spain

Ramirez A:
 Department of Psychiatry and Psychotherapy, Division of Neurogenetics and Molecular Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany

 Department of Neurodegenerative Diseases and Geriatric Psychiatry, Medical Faculty, University Hospital Bonn, Bonn, Germany

 DZNE Bonn, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany

 Department of Psychiatry and Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX, USA

 Cologne Excellence Cluster for Stress Responses in Ageing-associated Diseases (CECAD), University of Cologne, Cologne, Germany

Rauch S:
 Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA

Reichenberg A:
 Department of Mental Disorders, Norwegian Institute of Public Health, New York, NY, USA

Riddle MA:
 Department of Psychiatry and Behavioral Sciences, Child and Adolescent, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Ripke S:
 Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany

 Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA

 Site Berlin-Potsdam, German Center for Mental Health (DZPG), Berlin, Germany

Rosário MC:
 Department of Psychiatry, Child and Adolescent Psychiatry Unit (UPIA), Federal University of São Paulo (UNIFESP), São Paulo, Brazil

Sampaio AS:
 Department of Neurosciences and Mental Health, Medical School, Federal University of Bahia, Salvador, Brazil

Schiele MA:
 Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Freiburg, Medical Center-University of Freiburg, Freiburg, Germany

Skogholt AH:
 Department of Public Health and Nursing, HUNT Center for Molecular and Clinical Epidemiology, Trondheim, Norway

Sloofman LG:
 Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA

Smit J:
 Department of Psychiatry, Faculty of Medicine, Locaion VUmc, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

Artigas MS:
 Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain

 Department of Mental Health, Hospital Universitari Vall d'Hebron, Barcelona, Spain

 Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain

 Department of Genetics, Microbiology, and Statistics, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain

Thomas LF:
 Department of Clinical and Molecular Medicine, NTNU, Trondheim, Norway

 Department of Public Health and Nursing, K.G. Jebsen Center for Genetic Epidemiology, NTNU, Trondheim, Norway

 BioCore, Bioinformatics Core Facility, NTNU, Trondheim, Norway

 Clinic of Laboratory Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway

Tifft E:
 Obsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA

Vallada H:
 Department of Psychiatry, Universidade de São Paulo, São Paulo, Brazil

 Department of Molecular Medicine and Surgery, CMM, Karolinska Institutet, Stockholm, Sweden

van Kirk N:
 OCD Institute, Division of Depression and Anxiety, McLean Hospital, Belmont, MA, USA

 Department of Psychiatry, Harvard Medical School, Belmont, MA, USA

Veenstra-VanderWeele J:
 Department of Psychiatry, Division of Child and Adolescent Psychiatry, Columbia University, New York, NY, USA

 Department of Child and Adolescent Psychiatry, New York State Psychiatric Institute, New York, NY, USA

Vulink NN:
 Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

Walker CP:
 Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ, USA

Wang Y:
 Department of Neurology, the Johns Hopkins University School of Medicine, Baltimore, MD, USA

Wendland JR:
 Laboratory of Clinical Science, NIMH Intramural Research Program, Bethesda, MD, USA

Winsvold BS:
 Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway

 Department of Neurology, Oslo University Hospital, Oslo, Norway

 HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU, Trondheim, Norway

Yao Y:
 Department of Computional Biology, Institute of Life Science, Fudan University, Fudan, China

Zhou H:
 Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA

 Department of Psychiatry, Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA

 Section of Biomedical Informatics and Data Science, Yale School of Medicine, New Haven, CT, USA

Agrawal A:
 Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA

Alonso P:
 Department of Psychiatry, OCD Clinical and Research Unit, Bellvitge Hospital, Barcelona, Spain

 Department of Clinical Sciences, University of Barcelona, Barcelona, Spain

 Department of Psychiatry and Mental Health, Bellvitge Biomedical Research Institute IDIBELLL, Barcelona, Spain

 CIBERSAM, Mental Health Network Biomedical Research Center, Madrid, Spain

Berberich G:
 Psychosomatic Department, Windach Hospital of Neurobehavioural Research and Therapy, Windach, Germany

Bucholz KK:
 Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA

Bulik CM:
 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

 Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

 Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

Cath D:
 Departments of Rijksuniversiteit Groningen and Psychiatry, University Medical Center Groningen, Groningen, the Netherlands

 Department of Specialized Training, Drenthe Mental Health Care Institute, Groningen, the Netherlands

Denys D:
 Department of Psychiatry, Institute of the Royal Netherlands Academy of Arts and Sciences (NIN-KNAW), Amsterdam, the Netherlands

Eapen V:
 Discipline of Psychiatry and Mental Health, School of Clinical Medicine, UNSW, Sydney, New South Wales, Australia

 Academic Unit of Child Psychiatry South-West Sydney, South-West Sydney Clinical School, SWSLHD and Ingham Institute, Sydney, New South Wales, Australia

Edenberg H:
 Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA

Falkai P:
 Department of Psychiatry and Psychotherapy, University Hospital LMU, Munich, Germany

 Department of Psychiatry, Max Planck Institute, Munich, Germany

Fernandez TV:
 Child Study Center and Psychiatry, Yale School of Medicine, New Haven, CT, USA

Fyer AJ:
 Department of Psychiatry, New York State Psychiatric Institute, New York, NY, USA

 Department of Psychiatry, Columbia University Medical Center, New York, NY, USA

Gaziano JM:
 Department of Medicine, VA Boston Healthcare System, Boston, MA, USA

 Department of Medicine, Mass General Brigham, Boston, MA, USA

Geller DA:
 Department of Psychiatry, Harvard Medical School, Boston, MA, USA

 Department of Psychiatry, Child Psychiatry, Massachusetts General Hospital, Boston, MA, USA

Grabe HJ:
 Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany

Greenberg BD:
 COBRE Center on Neuromodulation, Butler Hospital, Providence, RI, USA

 Center for Neurorestoration and Neurotechnology, VA Providence Healthcare System, Providence, RI, USA

 Department of Psychiatry and Human Behavior, Alpert Medical School, Brown University, Providence, RI, USA

Hanna GL:
 Department of Psychiatry, Child and Adolescent Psychiatry, University of Michigan, Ann Arbor, MI, USA

Hickie IB:
 Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia

Hougaard DM:
 Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark

 Center for Genomics and Personalized Medicine, Aarhus, Denmark

Kathmann N:
 Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany

Kennedy J:
 Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada

Lai D:
 Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA

Landén M:
 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

 Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, University of Gothenburg, Gothenburg, Sweden

Hellard SL:
 Department of Clinical Science, University of Bergen, Bergen, Norway

 Bergen Center for Brain Plasticity, Division of Psychiatry, Haukeland University Hospital, Bergen, Norway

Leboyer M:
 Department of Addictology and Psychiatry, Université Paris-Est Créteil, AP-HP, Inserm, Paris, France

Lochner C:
 Department of Psychiatry, SA MRC Unit on Risk and Resilience in Mental Disorders, Stellenbosch University, Stellenbosch, South Africa

McCracken JT:
 Department of Psychiatry and Biobehavioral Sciences, Division of Child and Adolescent Psychiatry, University of California, Los Angeles, Los Angeles, CA, USA

Medland SE:
 Department of Mental Health, Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

Mortensen PB:
 Center for Genomics and Personalized Medicine, Aarhus, Denmark

 National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark

 Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Denmark

Neale BM:
 Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA

 Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA

Nicolini H:
 Department of Psychiatry, Psychiatry, Carracci Medical Group, Mexico City, México

 Psiquiatría, Instituto Nacional de Medicina Genómica, Mexico City, México

Nordentoft M:
 Mental Health Center Copenhagen, Copenhagen Research Center for Mental Health, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark

 Faculty of Health and Medical Sciences, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

Pato M:
 Department of Psychiatry, Rutgers University, Piscataway, NJ, USA

Pato C:
 Department of Psychiatry, Rutgers University, Piscataway, NJ, USA

Pauls DL:
 Department of Psychiatry, Harvard Medical School, Boston, MA, USA

Piacentini J:
 Department of Psychiatry and Biobehavioral Sciences, Child and Adolescent Psychiatry, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA

Pittenger C:
 Department of Psychiatry, Yale University, New Haven, CT, USA

Posthuma D:
 Department of Complex Trait Genetics, Vrije Universiteit Amsterdam, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Amsterdam, the Netherlands

 Department of Child and Adolescent Psychiatric, Section Complex Trait Genetics, VU Medical Center Amsterdam, Amsterdam, the Netherlands

Ramos-Quiroga JA:
 Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Spain

 Group of Psychiatry, Mental Health and Addictions, Psychiatric Genetics Unit, Vall d'Hebron Research Institute, Barcelona, Spain

 CIBERSAM, Barcelona, Spain

 Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain

Rasmussen SA:
 Department of Psychiatry and Human Behavior, Alpert Medical School, Brown University, Providence, RI, USA

Richter MA:
 Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada

 Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

Rosenberg DR:
 Department of Psychiatry and Behavioral Neurosciences, Child and Adolescent Psychiatry, Wayne State University School of Medicine, Detroit, MI, USA

Ruhrmann S:
 Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany

Samuels JF:
 Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

Sandin S:
 Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA

 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Sandor P:
 Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada

Spalletta G:
 Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy

 Department of Psychiatry and Behavioral Sciences, Division of Neuropsychiatry, Baylor College of Medicine, Houston, TX, USA

Stein DJ:
 Department of Psychiatry and Neuroscience Institute, SAMRC Unit on Risk and Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa

Stewart SE:
 Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada

 British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada

 British Columbia Mental Health and Substance Use Services Research Institute, Vancouver, British Columbia, Canada

Storch EA:
 Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA

Stranger BE:
 Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

 Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

Turiel M:
 Department of Cardiology, University of Milan, Milan, Italy

Werge T:
 Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Copenhagen University Hospital, Mental Health Services (RHP), Copenhagen, Denmark

 Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

Andreassen OA:
 Institute of Clinical Medicine, NORMENT Centre, University of Oslo, Oslo, Norway

 Division of Mental Health and Addiction, Center for Precision Psychiatry, Oslo University Hospital, Oslo, Norway

Børglum AD:
 Department of Biomedicine, Aarhus University, Aarhus, Denmark

 The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus University, Aarhus, Denmark

 Center for Genomics and Personalized Medicine, Aarhus University, Aarhus, Denmark

Walitza S:
 Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich (PUK), University of Zurich, Zürich, Switzerland

 Neuroscience Center Zurich, University of Zurich and the ETH Zurich, Zürich, Switzerland

 Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland

Hveem K:
 HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU, Trondheim, Norway

 HUNT Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU, Trondheim, Norway

 Department of Research, Innovation and Education, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway

Hansen BK:
 Bergen Center for Brain Plasticity, Psychiatry, Haukeland University Hospital, Bergen, Norway

 Centre for Crisis Psychology, Psychology, University of Bergen, Bergen, Norway

Rück C:
 Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Services, Region Stockholm, Stockholm, Sweden

Martin NG:
 Department of Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

Milani L:
 Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia

Mors O:
 Psychosis Research Unit, Psychiatry, Aarhus University Hospital, Aarhus, Denmark

Reichborn-Kjennerud T:
 Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway

 Institute of Clinical Medicine, University of Oslo, Oslo, Norway

Ribasés M:
 Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain

 Department of Mental Health, Hospital Universitari Vall d'Hebron, Barcelona, Spain

 Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain

 Department of Genetics, Microbiology, and Statistics, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain

Kvale G:
 Department of Mental Health, Norwegian University for Science and Technology, Trondheim, Norway

 Department of Clinical Psychology, Faculty of Psychology, University of Bergen, Bergen, Norway

Mataix-Cols D:
 Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Services, Region Stockholm, Stockholm, Sweden

Domschke K:
 Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Freiburg, Medical Center-University of Freiburg, Freiburg, Germany

 Partner Site Berlin, DZPG, Berlin, Germany

Grünblatt E:
 Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich (PUK), University of Zurich, Zürich, Switzerland

 Neuroscience Center Zurich, University of Zurich and the ETH Zurich, Zürich, Switzerland

 Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland

Wagner M:
 Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany

 Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany

 DZNE, Bonn, Germany

Zwart JA:
 HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU, Trondheim, Norway

 Department of Research and Innovation, Clinical Neuroscience, Oslo University Hospital and University of Oslo, Oslo, Norway

Breen G:
 Social, Genetic and Developmental Psychiatric Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK

Nestadt G:
 Department of Psychiatry and Behavioral Science, Johns Hopkins University, Baltimore, MD, USA

Kaprio J:
 FIMM, University of Helsinki, Helsinki, Finland

Arnold PD:
 Department of Psychiatry, the Mathison Centre for Mental Health Research and Education, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

 Program in Genetics and Genome Biology, Hospital for Sick Children, Toronto, Ontario, Canada

Grice DE:
 Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA

Knowles JA:
 Department of Genetics, Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ, USA

Ask H:
 PsychGen Center for Genetic Epidemiology, Norwegian Institute of Public Health, Oslo, Norway

 PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway

Verweij KJ:
 Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

Davis LK:
 Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA

Smit DJ:
 Department of Psychiatry, Amsterdam UMC location AMC, Amsterdam, the Netherlands

Crowley JJ:
 Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Services, Region Stockholm, Stockholm, Sweden

 Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

 Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

Scharf JM:
 Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA

 Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA

Stein MB:
 Psychiatry Service, VA San Diego Healthcare System, San Diego, CA, USA

 Department of Psychiatry and School of Public Health, University of California San Diego, La Jolla, CA, USA

Gelernter J:
 Department of Psychiatry, Human Genetics (Psychiatry), Yale University School of Medicine, West Haven, CT, USA

 Department of Psychiatry, Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA

Mathews CA:
 Psychiatry and Genetics Institute, Evelyn F. and William L. Mc Knight Brain Institute, Center for OCD, Anxiety and Related Disorders, University of Florida, Gainesville, FL, USA

Derks EM:
 Department of Mental Health and Neuroscience, QIMR Berghofer, Brisbane, Queensland, Australia

Mattheisen M:
 Department of Psychiatric Phenomics and Genomics (IPPG), Ludwig-Maximilians University Munich, Munich, Germany

 Department of Biomedicine, Aarhus University, Aarhus, Denmark

 Department of Community Health and Epidemiology and Faculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada