Transvaginal ultrasound assessment of corpus callosal length in the fetus: multicenter cross-sectional study
Por:
Paladini, D, Parodi, S, Xie, H, Viñals, F, Haratz, K, Birnbaum, R, Azumendi, G, Pomar, L, Montaguti, E, Acharya, P, Volpe, P, Pérez-Cruz M, Katrin, K, Chaoui, R and Pooh, R
Publicada:
1 jun 2025
Ahead of Print:
1 may 2025
Resumen:
ObjectiveTo produce reference ranges and Z-scores for corpus callosal (CC) length in the fetus, based on transvaginal three-dimensional (3D) ultrasound imaging.MethodsThis was a cross-sectional multicenter retrospective study based on 3D volume dataset acquisitions of the fetal CC between the 15th and 37th weeks of gestation. Only volume datasets acquired transvaginally through the anterior fontanelle were selected. After plane alignment on multiplanar imaging, the length of the CC was measured edge-to-edge on magnified images. Intra- and interobserver variability were assessed and the related intraclass correlation coefficients (ICC) calculated. Biometric charts to assess the reference values for fetal CC were obtained using the method proposed by Altman in 1993.ResultsThe 13 participating centers provided valid data for 2131 patients. Excellent agreement was observed for both intra- and interobserver analysis, with an ICC range of 0.98-1.00. A quadratic model was used for construction of the reference charts, modified with the insertion of cubic spline coefficients with a single knot at 18 gestational weeks, to recover an apparent lack of fit at lower gestational ages. Centile reference values and the corresponding Z-scores were produced for CC length between 15 and 37 gestational weeks.ConclusionsThis multicenter study presents growth charts for the fetal CC, addressing the critical methodological weaknesses of several previous studies. An even distribution of cases across all gestational weeks, robust statistical methodology and a standardized, high-resolution transvaginal neurosonographic technique represent key factors supporting the reliability of the biometric curves presented here. (c) 2025 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
Filiaciones:
Paladini, D:
IRCCS Ist Giannina Gaslini, Fetal Med & Surg Unit, Genoa, Italy
Parodi, S:
IRCCS Ist Giannina Gaslini, Unit Epidemiol & Biostat, Sci Directorate, Genoa, Italy
Xie, H:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Ultrason Med, Guangzhou, Guangdong, Peoples R China
Viñals, F:
Sanatorio Aleman Clin, Ultrasound Dept, Concepcion, Chile
Univ Concepcion, Fac Med, Obstet Dept, Concepcion, Chile
Haratz, K:
Tel Aviv Sourasky Med Ctr, Lis Matern Hosp, OB GYN Ultrasound Unit, Tel Aviv, Israel
Tel Aviv Univ, Fac Med, Tel Aviv, Israel
Birnbaum, R:
Tel Aviv Sourasky Med Ctr, Lis Matern Hosp, OB GYN Ultrasound Unit, Tel Aviv, Israel
Tel Aviv Univ, Fac Med, Tel Aviv, Israel
Azumendi, G:
Ctr Gutenberg, Ultrasound & Fetal Med Unit, Malaga, Spain
Pomar, L:
Lausanne Univ Hosp, Dept Woman Mother Child, Ultrasound & Fetal Med Unit, Lausanne, Switzerland
Univ Lausanne, Lausanne, Switzerland
HES SO Univ Appl Sci & Arts Western Switzerland, Sch Hlth Sci HESAV, Lausanne, Switzerland
Montaguti, E:
IRCCS Azienda Osped Univ Bologna, Obstet Unit, Bologna, Italy
Acharya, P:
Paras Adv Ctr Fetal Med, Ahmadabad, India
Volpe, P:
Venere Hosp, Dept Human Reprod, Fetal Med Unit, Bari, Italy
Pérez-Cruz M:
Univ Barcelona, Hosp Clin, BCNatal Fetal Med Res Ctr, Barcelona, Spain
Univ Barcelona, Hosp St Joan Deu, Barcelona, Spain
Inst Recerca St Joan Deu, Barcelona, Spain
Inst Salud Carlos III, Primary Care Intervent Prevent Maternal & Child Ch, Madrid, Spain
Katrin, K:
Ctr Prenatal Diag Munich, Munich, Germany
Chaoui, R:
Feindiagnostik, Berlin, Germany
Pooh, R:
CRIFM Prenatal Med Clin, Fetal Brain Ctr, Osaka, Japan
Green Submitted, hybrid
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