Tuberculosis household contact tracing in children: axes of inequality, Barcelona 2003-2022
Por:
Prieto-García R, Millet JP, Soriano-Arandes A, Espiau M, Broto C, Ronda M, López N, Noguera-Julian A, Masdeu Corcoll E, Domingo Jimenez C, Ros Samsó M, Marcos Arroita MI, Ospina Valencia JE, García Rebollo C, Simon Viván P and Rius Gibert C
Publicada:
29 may 2025
Ahead of Print:
29 may 2025
Resumen:
Children under 15 years of age living in the household of a tuberculosis case constitute a very vulnerable group to tuberculosis infection (TBI). The objective of this study was to determine the prevalence of TBI and the risk factors associated with presenting TBI in this group, considering sex, age, and migratory status as axes of inequality. A population-based, analytical, cross-sectional observational study was carried out in the city of Barcelona in the period 2003-2022. The study population was household contacts under 15 years of age with index cases of pulmonary TB reported to the Barcelona Public Health Agency in the period 2003-2022. The analyses were performed using Generalized Estimating Equations (GEE) to predict the risk of TBI among these cohabiting contacts and were stratified considering the inequality axes of sex and migratory status. A total of 1084 contacts under 15 years of age were studied from 693 cases of tuberculosis. TBI prevalence among contacts was 24.5%. The factors associated with the presence of TBI in the contacts were having a smear positive in the index case, being older than 5 years in the contacts ([5,10], [10-15]) and the case and the contact being migrants; smear positive when the index case was native women and being from a municipal district with a lower incidence of tuberculosis when the index case was native women and the men. The results of the study confirm the importance of carrying out contact tracing and follow-up of household children, especially if the index case is smear positive. Contact tracing should be carried out as soon as possible to assess the prescription of primary chemoprophylaxis and TBI treatment to avoid rapid TB progression in children.
Filiaciones:
Prieto-García R:
Departament de Ciències Experimentals i de la Salut (DCEXS). Universitat Pompeu Fabra, Barcelona, Spain
Servei d'Epidemiologia (SEPID), Agència de Salut Pública de Barcelona (ASPB), Barcelona, Spain
Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (IIB Sant Pau), Barcelona, Spain
CIBER de Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
Millet JP:
Servei d'Epidemiologia (SEPID), Agència de Salut Pública de Barcelona (ASPB), Barcelona, Spain
Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (IIB Sant Pau), Barcelona, Spain
CIBER de Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
Soriano-Arandes A:
Unitat de Patologia Infecciosa i Immunodeficiències de Pediatria, Hospital Universitari Vall d'Hebron, Barcelona, Spain
Espiau M:
Unitat de Patologia Infecciosa i Immunodeficiències de Pediatria, Hospital Universitari Vall d'Hebron, Barcelona, Spain
Broto C:
Unitat de Patologia Infecciosa i Immunodeficiències de Pediatria, Hospital Universitari Vall d'Hebron, Barcelona, Spain
Ronda M:
Departament de Malalties Infeccioses, Hospital Universitari de Bellvitge, l'Hospitalet del Llobregat, Barcelona, Spain
López N:
Servicio de Pediatría, Hospital del Mar, Barcelona, Spain
Noguera-Julian A:
Malalties Infeccioses I Resposta Inflamatòria Sistèmica en Pediatria, Servei de Malalties Infeccioses I Patologia Importada, Institut de Recerca Pediàtrica Sant Joan de Déu, Barcelona, Spain
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Departament de Cirurgia i Especialitats Medicoquirúrgiques, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain
Masdeu Corcoll E:
Servei d'Epidemiologia (SEPID), Agència de Salut Pública de Barcelona (ASPB), Barcelona, Spain
Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (IIB Sant Pau), Barcelona, Spain
Domingo Jimenez C:
Servei d'Epidemiologia (SEPID), Agència de Salut Pública de Barcelona (ASPB), Barcelona, Spain
Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (IIB Sant Pau), Barcelona, Spain
Ros Samsó M:
Servei d'Epidemiologia (SEPID), Agència de Salut Pública de Barcelona (ASPB), Barcelona, Spain
Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (IIB Sant Pau), Barcelona, Spain
Marcos Arroita MI:
Servei d'Epidemiologia (SEPID), Agència de Salut Pública de Barcelona (ASPB), Barcelona, Spain
Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (IIB Sant Pau), Barcelona, Spain
Ospina Valencia JE:
Servei d'Epidemiologia (SEPID), Agència de Salut Pública de Barcelona (ASPB), Barcelona, Spain
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
García Rebollo C:
Malalties Infeccioses I Resposta Inflamatòria Sistèmica en Pediatria, Servei de Malalties Infeccioses I Patologia Importada, Institut de Recerca Pediàtrica Sant Joan de Déu, Barcelona, Spain
Simon Viván P:
Departament de Ciències Experimentals i de la Salut (DCEXS). Universitat Pompeu Fabra, Barcelona, Spain
Servei d'Epidemiologia (SEPID), Agència de Salut Pública de Barcelona (ASPB), Barcelona, Spain
Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (IIB Sant Pau), Barcelona, Spain
CIBER de Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
Rius Gibert C:
Departament de Ciències Experimentals i de la Salut (DCEXS). Universitat Pompeu Fabra, Barcelona, Spain
Servei d'Epidemiologia (SEPID), Agència de Salut Pública de Barcelona (ASPB), Barcelona, Spain
Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (IIB Sant Pau), Barcelona, Spain
CIBER de Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
Green Submitted, Green Published, gold
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