Dietary patterns and exposure to non-persistent endocrine-disrupting chemicals during pregnancy
Por:
Warkentin S, Márquez S, Vespalcová H, Knox B, Gascon M, Güil-Oumrait N, González-Palacios S, Gómez-Roig MD, Lassale C, Llurba E, Rolland M, Sakhi AK, Thomsen C, Vioque J, Bustamante M, Sunyer J and Vrijheid M
Publicada:
1 ago 2025
Ahead of Print:
1 jun 2025
Resumen:
Background: Exposure to non-persistent endocrine disrupting chemicals (EDCs) is widespread, causing various adverse health effects, especially during pregnancy. Diet is a major source of EDCs and the identification of dietary patterns that give rise to higher exposure levels is crucial. We aimed to explore the relationship between dietary patterns during pregnancy and exposure to non-persistent EDCs. Methods: We included 640 pregnant women from the Barcelona Life Study Cohort (BiSC), Spain. Using food frequency questionnaires (2nd trimester), we estimated ultraprocessed food (UPF) consumption and Mediterranean diet adherence, and derived data-driven dietary patterns. Metabolites of phthalates, 1,2-cyclohexane dicarboxylic acid di(isononyl) ester (DINCH), chlorpyrifos and pyrethroid, polycyclic aromatic hydrocarbons (PAHs, including phenanthrenes), and organophosphates, and parent compounds of phenols and parabens were measured in weekly urine pools (3rd trimester). Associations between dietary patterns and EDCs were evaluated through multivariable linear regressions. Results: Higher compliance with a "Vegetarian" pattern or the Mediterranean diet was associated with lower levels of some of the phthalate metabolites (e.g., di-iso-nonyl phthalates [Geometric mean ratio (GMR) per unit increases in the "Vegetarian" score = 0.97, 95 %CI 0.95, 1.00]). Conversely, "Western" and "Animal protein" patterns, and UPF intake were associated with higher PAHs (e.g., "Western" and 2-Hydroxynaphthalene [GMR (95 %CI) 1.07(1.01, 1.13)]), pesticides (e.g., "Animal protein" and 3-Phenoxybenzoic acid [1.15(1.01, 1.32]), and phthalates metabolites levels (e.g., UPF and Monoethyl phthalate [1.05(1.01, 1.09)]). No association remained significant after correcting for multiple testing. Conclusions: Following a plant-based diet may help reduce the exposure to certain phthalate and organophosphate metabolites, whereas higher consumption of foods from animal origin and high in fat/sugar/salt may increase exposure to PAHs, pesticides, and phthalates metabolites in pregnancy.
Filiaciones:
Warkentin S:
ISGlobal, Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Márquez S:
ISGlobal, Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Vespalcová H:
ISGlobal, Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Knox B:
ISGlobal, Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Gascon M:
ISGlobal, Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Unitat de Suport a la Recerca de la Catalunya Central, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Manresa, Spain
Güil-Oumrait N:
ISGlobal, Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
González-Palacios S:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Universidad Miguel Hernández, Instituto de Investigación Sanitaria y Biomédica de Alicante (UMH-ISABIAL), Alicante, Spain
Gómez-Roig MD:
Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin Network (RICORS), RD21/0012/0003, Instituto de Salud Carlos III, Madrid, Spain
BCNatal, Fetal Medicine Research Center, Hospital Sant Joan de Déu and Hospital Clínic, University of Barcelona, Barcelona, Spain
Institut de Recerca Sant Joan de Déu, Barcelona, Spain
Lassale C:
ISGlobal, Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Consortium for Biomedical Research - Pathophysiology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain
Llurba E:
Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin Network (RICORS), RD21/0012/0003, Instituto de Salud Carlos III, Madrid, Spain
Department of Obstetrics and Gynaecology, Institut d'Investigació Biomèdica Sant Pau-IIB Sant Pau. Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Rolland M:
University Grenoble Alpes, Inserm, U1209, CNRS UMR 5309, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Institute for Advanced Biosciences, 38000 Grenoble, France
Sakhi AK:
Department of Food Safety, Norwegian Institute of Public Health, Oslo, Norway
Thomsen C:
Department of Food Safety, Norwegian Institute of Public Health, Oslo, Norway
Vioque J:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Universidad Miguel Hernández, Instituto de Investigación Sanitaria y Biomédica de Alicante (UMH-ISABIAL), Alicante, Spain
Bustamante M:
ISGlobal, Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Sunyer J:
ISGlobal, Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Catalonia, Spain
Vrijheid M:
ISGlobal, Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Green Submitted, gold
|