Association between dynapenic abdominal obesity and mild cognitive impairment among middle-aged and older community-dwelling adults
Por:
Smith L, López Sánchez GF, Soysal P, Veronese N, Rahmati M, Kostev K, Jacob L., Tully MA, Richardson F, Butler L, Barnett Y, Keyes H, Shin JI and Koyanagi A
Publicada:
28 jul 2025
Ahead of Print:
28 jul 2025
Resumen:
Objectives Dynapenic abdominal obesity (DAO) may potentially increase risk for mild cognitive impairment (MCI), but data is scarce, and community-based studies are lacking. Thus, we aimed to investigate the association between DAO and MCI in a large nationally representative community-based sample from six LMICs (China, Ghana, India, Mexico, Russia, South Africa). Methods We analyzed cross-sectional data from the Study on Global Ageing and Adult Health. Dynapenia was defined as handgrip strength of < 26 kg for men and < 16 kg for women. Abdominal obesity was defined as waist circumference of > 88 cm for women and > 102 cm for men. DAO was defined as having both dynapenia and abdominal obesity. The National Institute on Ageing-Alzheimer's Association criteria were used to define MCI. Multivariable logistic regression was performed. Results Data on 32,715 individuals aged >= 50 years were analyzed [mean (SD) age 62.1 (15.6) years; 48.3% males]. Among those aged 50-64 years, dynapenia alone and DAO were significantly associated with MCI with the OR for DAO (OR = 1.79; 95%CI = 1.26-2.56) being higher than that of dynapenia alone (OR = 1.40; 95%CI = 1.15-1.71). In those aged >= 65 years, only dynapenia alone (OR = 1.53; 95%CI = 1.23-1.89) was significantly associated with MCI but not DAO. Abdominal obesity alone was not significantly associated with MCI in both age groups. Conclusions Among community-dwellers in six LMICs, DAO was significantly associated with MCI among middle-aged individuals, but not among older people. However, it is important to note that the study was cross-sectional in nature, and thus, it is not known whether DAO leads to MCI or vice versa. Therefore, future longitudinal studies are necessary to clarify temporal associations and possible causality.
Filiaciones:
Smith L:
Centre for Health Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK
Department of Public Health, Faculty of Medicine, Biruni University, Istanbul, Turkey
López Sánchez GF:
Division of Preventive Medicine and Public Health, Department of Public Health Sciences, School of Medicine, University of Murcia, Murcia, Spain
Soysal P:
Department of geriatric Medicine, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
Veronese N:
Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Palermo, Italy
Rahmati M:
Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran
Department of Physical Education and Sport Sciences, Faculty of Literature and Humanities, Vali-E-Asr University of Rafsanjan, Rafsanjan, Iran
Kostev K:
University Clinic of Marburg, Marburg, Germany
Jacob L.:
Research and Development Unit, Parc Sanitari Sant Joan de Déu, Dr. Antoni Pujadas, Sant Boi de Llobregat, Barcelona, Spain
AP-HP, Department of Physical Medicine and Rehabilitation, Université Paris Cité, Lariboisière-Fernand Widal Hospital, Paris, France
U1153, Epidemiology of Ageing and Neurodegenerative Diseases (EpiAgeing), Inserm - Université Paris Cité, Paris, France
Tully MA:
School of Medicine, Ulster University, Londonderry, Northern Ireland, UK
Richardson F:
The Queen Elizabeth Hospital King's Lynn NHS Foundation Trust, King's Lynn, PE30 4ET, UK
Butler L:
Centre for Health Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK
Barnett Y:
Centre for Health Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK
Keyes H:
School of Psychology, Sport and Sensory Sciences, Anglia Ruskin University, Cambridge, UK
Shin JI:
Department of Pediatrics, Yonsei University College of Medicine, Seoul, South Korea
Severance Underwood Meta-Research Center, Institute of Convergence Science, Yonsei University, Seoul, Republic of Korea
Koyanagi A:
Research and Development Unit, Parc Sanitari Sant Joan de Déu, Dr. Antoni Pujadas, Sant Boi de Llobregat, Barcelona, Spain
Green Submitted, hybrid
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