Intraparietal sulcus depth is associated with negative symptomatology in patients with first-episode psychosis.
Por:
Nuñez C, Serra C, Butjosa A, Amoretti S, Martinez-Aran A, Janssen J, Mezquida G, Vieta E, Andrés-Camazón P, Cuesta MJ, Bergé D, de la Serna E, Stephan-Otto C, Usall J and Bernardo M
Publicada:
1 oct 2025
Ahead of Print:
25 ago 2025
Resumen:
The study of brain morphology parameters in patients with first-episode psychosis (FEP) could help detect early brain footprints related to this disease and its predominant symptomatology. We examined gray matter (GM) volume, cortical thickness (CT), gyrification index (GI), and sulcus depth (SD) differences between patients with FEP and healthy control (HC) participants. We also investigated the associations of these brain parameters with symptomatology in FEP. Our sample consisted of 182 participants, 105 patients with FEP and 77 HC. All participants had a brain structural image acquired with a 3T scanner. Symptomatology was assessed with the Positive and Negative Syndrome Scale (PANSS), considering both the original 3-factor structure and an alternative 5-factor structure proposed by Emsley. Patients with FEP showed reduced GM volume than HC in the anterior cingulate gyrus and adjacent regions. We also found that greater SD of the intraparietal sulcus was associated with more severe negative symptomatology in FEP. This association was found with the total score of this subscale and several of its items. Additionally, lower SD and lower CT in the right parietal lobe were associated with a higher Emsley's excited factor score, which includes items related to manic symptoms. Our results suggest that an abnormal depth of the intraparietal sulcus may be an indicator of impaired functioning of this region, which may in turn be associated with social and emotional issues. Overall, SD seems to provide relevant information on the brain morphology of FEP, making it a promising marker for the early stages of psychosis.
Filiaciones:
Nuñez C:
Mental Health Research Group, Institut d'Investigació Biomèdica Sant Pau (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain
Fundació de Recerca Clínic Barcelona - Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Serra C:
Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain
Butjosa A:
Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain
Amoretti S:
Centro de Investigación Biomédica en Red Salud Mental (CIBERSAM), Madrid, Spain
Group of Psychiatry, Mental Health and Addictions, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain
Martinez-Aran A:
Centro de Investigación Biomédica en Red Salud Mental (CIBERSAM), Madrid, Spain
Institute of Neuroscience, University of Barcelona, Hospital Clinic, IDIBAPS, Barcelona, Spain
Janssen J:
Centro de Investigación Biomédica en Red Salud Mental (CIBERSAM), Madrid, Spain
Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, Madrid, Spain
Mezquida G:
Centro de Investigación Biomédica en Red Salud Mental (CIBERSAM), Madrid, Spain
Serra-Hunter Fellow, Department of Basic Clinal Practice, Pharmacology Unit, University of Barcelona, Barcelona, Spain
Barcelona Clinic Schizophrenia Unit, Hospital Clínic de Barcelona
Departament de Medicina, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB)
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Vieta E:
Centro de Investigación Biomédica en Red Salud Mental (CIBERSAM), Madrid, Spain
Institute of Neuroscience, University of Barcelona, Hospital Clinic, IDIBAPS, Barcelona, Spain
Andrés-Camazón P:
Centro de Investigación Biomédica en Red Salud Mental (CIBERSAM), Madrid, Spain
Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, Madrid, Spain
Cuesta MJ:
Department of Psychiatry, Hospital Universitario de Navarra, Pamplona, Spain
Navarra Institute for Health Research (IdiSNA), Pamplona, Spain
Bergé D:
Centro de Investigación Biomédica en Red Salud Mental (CIBERSAM), Madrid, Spain
Hospital del Mar Research Institute, Universitat Pompeu Fabra, Barcelona, Spain
de la Serna E:
Fundació de Recerca Clínic Barcelona - Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Centro de Investigación Biomédica en Red Salud Mental (CIBERSAM), Madrid, Spain
Department of Child and Adolescent Psychiatry and Psychology, Institut Clinic de Neurociències, Hospital Clínic Universitari, Barcelona, Spain
Stephan-Otto C:
Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain
Centro de Investigación Biomédica en Red Salud Mental (CIBERSAM), Madrid, Spain
Usall J:
Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain
Centro de Investigación Biomédica en Red Salud Mental (CIBERSAM), Madrid, Spain
Bernardo M:
Emeritus Consultant. Barcelona Clínic Schizophrenia Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain
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