Common variable immunodeficiency.
Por:
Solanich, Xavier, Antoli, Arnau and Alsina L
Publicada:
1 nov 2025
Ahead of Print:
3 oct 2025
Resumen:
Common variable immunodeficiency (CVID) is characterized by defective differentiation of B lymphocytes, hypogammaglobulinemia, and infections, although its clinical presentation is much more heterogeneous, with autoimmunity, interstitial lung disease, enteropathy, lymphoproliferation, malignancy, among others. Patients with CVID should undergo extensive immunological evaluations and regular assessment of the multiple organs that may be affected, ideally by multidisciplinary teams specialized in immunodeficiencies. Infections usually improve significantly after the initiation of immunoglobulin replacement therapy and other preventive measures, with non-infectious manifestations now posing the greatest therapeutic challenge. Identifying a genetic cause allows for the reclassification of patients, it has prognostic and therapeutic implications, and enables genetic counseling for family members.
Filiaciones:
Unidad de Inmunodeficiencias Primarias. Servicio de Medicina Interna. Hospital Universitari de Bellvitge. L'Hospitalet de Llobregat, Barcelona, Espana
Instituto de Investigacion Biomedica de Bellvitge (IDIBELL). L'Hospitalet de Llobregat, Barcelona, Espana
Departamento de Ciencias Clinicas, Facultad de Medicina y Ciencias de la Salud, Universitat de Barcelona, Barcelona, Espana
Unidad de Inmunologia Clinica e Inmunodeficiencias Primarias, Servicio de Alergologia e Inmunologia Clinica Pediatricas, Hospital Sant Joan de Deu, Barcelona, Espana
Unidad de Inmunologia Clinica, Hospital Sant Joan de Deu - Hospital Clinic de Barcelona, Barcelona, Espana
Departamento de Cirugia y Especialidades Medicoquirurgica, Universitat de Barcelona, Barcelona, Espana
Grupo de Estudio de Enfermedades por Disfuncion Inmune en Pediatria (GEMDIP). Institut de Recerca Sant Joan de Deu (IRSJD), Barcelona, Espana
|