EndoCompass project: research roadmap for reproductive and developmental endocrinology.
Por:
Cools M, Krausz C, Juul A, Macut D, Andersen MS, Andersson AM, Andoniadou CL, Ahmed SF, Bakker J, Bashamboo A, Behre HM, Bonomi M, Busch AS, De Roo C, Dessens A, Fakhar-I-Adil M, Fanelli F, Fisher AD, Flück C, Gambineri A, Giwercman A, Gravholt CH, Hannema S, Heindryckx B, Hiort O, Hornig NC, Howard S, Ibañez-Toda L, Blomberg Jensen M, Jørgensen N, Livadas S, Lucas-Herald A, Mastorakos G, Meriggiola MC, Ong K, Opalic Palibrk M, Pignatelli D, Pitteloud N, Rajpert-De Meyts E, Rey R, Robeva R, Pozza C, Schlatt S, Spaggiari G, Tack L, Tena-Sempere M, Tournaye H, T'Sjoen G, Van Mello N, Vena W, Yildiz BO and de Zegher F
Publicada:
17 oct 2025
Resumen:
BACKGROUND: Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project-a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges. METHODS: Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups. RESULTS: Research priorities encompass variations in sex development, hypothalamic-pituitary-gonadal regulation, and female and male reproductive disorders. Key areas include improving diagnostic capacity through (epi)genetic analysis, optimizing hormonal treatments, developing fertility preservation strategies. Special emphasis is placed on establishing pan-European registries, developing novel reproductive technologies, and exploring environmental impacts on reproductive health. CONCLUSIONS: This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into reproductive and developmental endocrinology pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of these disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of the highest potential impact in endocrine health.
Filiaciones:
Cools M:
Department of Internal Medicine and Paediatrics, Ghent University
Department of Paediatric Endocrinology, Ghent University Hospital, Ghent 9000, Belgium
Krausz C:
Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence 50139, Italy
Careggi University Hospital, Florence 50139, Italy
Juul A:
Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark
Rigshospitalet, Department of Clinical Medicine, University of Copenhagen, International Research and Research Training Center in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
Macut D:
Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Faculty of Medicine University of Belgrade, Belgrade 11000, Serbia
Andersen MS:
Endocrinology, Odense Universitetshospital, Odense 5000, Denmark
University of Southern Denmark, Odense, Denmark
Andersson AM:
Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark
Rigshospitalet, Department of Clinical Medicine, University of Copenhagen, International Research and Research Training Center in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
Andoniadou CL:
Centre for Craniofacial and Regenerative Biology, King's College London, Faculty of Dentistry, Oral and Craniofacial Sciences, London WC2R 2LS, United Kingdom
Department of Medicine III, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
Ahmed SF:
Developmental Endocrinology Research Group, University of Glasgow, Glasgow, United Kingdom
Bakker J:
Département des sciences biomédicales et précliniques Biologie de la différenciation sexuelle du cerveau GIGA Neurosciences-Neuroendocrinology, University of Liege, Liège, Walloon Region, Belgium
Bashamboo A:
Human Developmental Genetics Unit, CNRS (UMR 373), Institut Pasteur, Université Paris Cité, Paris 75015, France
Behre HM:
Center for Reproductive Medicine and Andrology, University of Halle, Halle, Germany
Bonomi M:
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
Department of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan 20133, Italy
Busch AS:
Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark
De Roo C:
Department for Reproductive Medicine, Ghent University Hospital, Ghent 9000, Belgium
Dessens A:
Department of Internal Medicine and Paediatrics, Ghent University
Department of Child and Adolescent Psychiatry, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands
Fakhar-I-Adil M:
Ghent-Fertility And Stem cell Team (G-FaST), Department for Reproductive Medicine, Department of Human Structure and Repair, Ghent University Hospital, Ghent 9000, Belgium
Fanelli F:
Department of Medical and Surgical Sciences, University of Bologna Hospital of Bologna Sant'Orsola-Malpighi Polyclinic, Bologna, Emilia-Romagna, Italy
Fisher AD:
Careggi University Hospital, Florence 50139, Italy
Flück C:
Pediatric Endocrinology, Diabetology and Metabolism, University Childrens Hospital, Bern, Switzerland
Gambineri A:
Department of Medical and Surgical Sciences, University of Bologna Hospital of Bologna Sant'Orsola-Malpighi Polyclinic, Bologna, Emilia-Romagna, Italy
Division of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria di Bologna Policlinico S Orsola, Bologna, Italy
Giwercman A:
Deparment of Translational Medicine, Lund University, Malmö, Sweden
Gravholt CH:
Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
Department of Clinical Medicine, Health, Aarhus University, Aarhus, Denmark
Aarhus University and Department of Endocrinology, Aarhus University Hospital, Aarhus, Denmark
Hannema S:
Department of Paediatrics, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands
Amsterdam Reproduction and Development, Amsterdam, The Netherlands
Heindryckx B:
Ghent-Fertility And Stem cell Team (G-FaST), Department for Reproductive Medicine, Department of Human Structure and Repair, Ghent University Hospital, Ghent 9000, Belgium
Hiort O:
Division of Paediatric Endocrinology and Diabetes, Department of Paediatrics and Adolescent Medicine, University of Lübeck, Lübeck, Germany
Hornig NC:
Institute of Human Genetics, Christian-Albrechts-University of Kiel, Kiel, Germany
Howard S:
Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom
Department of Paediatric Endocrinology, Barts Health NHS Trust, London E1 1BB, United Kingdom
Ibañez-Toda L:
Department of Endocrinology, Hospital Sant Joan de Déu, Esplugues, Barcelona, Spain
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), ISCIII, Madrid, Spain
Blomberg Jensen M:
Division of Translational Endocrinology, Department of Endocrinology and Internal Medicine, Copenhagen University Hospital - Herlev and Gentofte, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Jørgensen N:
Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark
Rigshospitalet, Department of Clinical Medicine, University of Copenhagen, International Research and Research Training Center in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
Livadas S:
Unit of Endocrinology, Athens Medical Centre, Athens, Greece
Lucas-Herald A:
Developmental Endocrinology Research Group, University of Glasgow, Glasgow, United Kingdom
Mastorakos G:
Faculty of Medicine, Endocrine Unit, "Aretaieion" Hospital, National and Kapodistrian University of Athens, Athens University, Athens, Greece
Meriggiola MC:
Department of Medical and Surgical Sciences, University of Bologna Hospital of Bologna Sant'Orsola-Malpighi Polyclinic, Bologna, Emilia-Romagna, Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S Orsola, Division of Gynecology and Physiopathology of Human Reproduction, University of Bologna, Bologna, Emilia-Romagna, Italy
Ong K:
MRC Epidemiology Unit-Childhood Obesity, Cambridge, United Kingdom
Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom
Opalic Palibrk M:
Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Faculty of Medicine University of Belgrade, Belgrade 11000, Serbia
Pignatelli D:
Faculty of Medicine, University of Porto, Porto, Portugal
Hospital S Joao, Porto, Portugal
Pitteloud N:
CHUV-EDM, Lausanne, Switzerland
Rajpert-De Meyts E:
Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark
Rey R:
CONICET-FEI-División Endocrinología, Centro de Investigaciones Endocrinológicas "Dr. César Bergadá" (CEDIE), Hospital de Niños R Gutiérrez, Buenos Aires 1330, Argentina
Robeva R:
Medical University-Sofia, MF, Department of Endocrinology, USHATE "Acad. Iv. Penchev", Sofia 1431, Bulgaria
Pozza C:
Department of Experimental Medicine, Sapienza University of Rome, Rome 00161 Italy
Schlatt S:
CeRA, Univ Münster, Münster 48149, Germany
Spaggiari G:
Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria of Modena, Modena 41126, Italy
Tack L:
Department of Internal Medicine and Paediatrics, Ghent University
Department of Paediatric Endocrinology, Ghent University Hospital, Ghent 9000, Belgium
Tena-Sempere M:
Physiology Section, Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC), Cordoba, Spain
CIBER Fisiopatologia de la Obesidad y Nutrición (CIBEROBN), University of Cordoba, Cordoba, Spain
Tournaye H:
Brussels IVF, the Centre for Reproductive Medicine of the Dutch-speaking Brussels Free University Hospital VUB, 101, Laarbeeklaan, Brussels 1090, Belgium
T'Sjoen G:
Endocrinology, University Hospital Gent, Gent 9000, Belgium
Van Mello N:
Center of Expertise on Gender Dysphoria, Amsterdam UMC Location AMC, Amsterdam 1118 1081, The Netherlands
Vena W:
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan 20090, Italy
Endocrinology and Diabetology Center, Humanitas Gavazzeni Institute, Bergamo 24125, Italy
Yildiz BO:
Department of Internal Medicine, Division of Endocrinology and Metabolism, Hacettepe University School of Medicine, Ankara 06100, Turkey
de Zegher F:
Department of Development and Regeneration, Woman and Child, University of Leuven, Leuven 3000, Belgium
Green Submitted, Green Published, hybrid
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