Maternal dietary phylloquinone intake (vitamin K1) and early childhood neurodevelopment.
Por:
Mateu-Fabregat J, Panisello L, Novau-Ferré N, Pinar-Martí A, Jimenez-Arenas P, Ferrer M, Rivas I, Llurba E, Lassale C, Gómez-Roig MD, Vioque J, González-Palacios S, Contreras-Rodríguez O, Arija V, Foraster M, Gascon M, Dadvand P, Sunyer J, Júlvez J and Bulló M
Ahead of Print:
21 oct 2025
Resumen:
BACKGROUND: Maternal nutrition is a crucial modifiable factor with phylloquinone being involved in processes related to optimal brain development. This study aimed to evaluate the associations between maternal phylloquinone intake during pregnancy and early neurodevelopment in children. METHODS: This study included 1080 pregnant women and their offspring from the Barcelona Life Study Cohort (BiSC). Maternal phylloquinone intake during pregnancy was estimated using a validated semiquantitative 114-item food frequency questionnaire. The Developmental Profile 3 (DP-3) and the Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III) were administered during early childhood. Statistical analysis was conducted using multivariable linear mixed-effects models and linear regression models. RESULTS: Higher maternal dietary phylloquinone intake during pregnancy was associated with increased global developmental index scores (ß [95% CI]: 0.88 [0.10, 1.66]) and better cognitive (ß [95% CI]: 0.87 [0.14, 1.60]) and physical development (ß [95% CI]: 0.72 [0.02, 1.42]), based on DP-3 scores. Similarly, motor development assessed through BSID-III scores was consistently higher in offspring of mothers within the highest phylloquinone intake (ß [95% CI]: 1.69 [0.008, 3.38]). CONCLUSION: Higher dietary phylloquinone intake during pregnancy was associated with improved offspring neurodevelopment, emphasizing the need for tailored recommendations during pregnancy to support optimal brain development. IMPACT: Prenatal maternal nutrition has been recognized as a critical modifiable factor influencing optimal brain development. No previous studies have examined the impact of maternal phylloquinone intake during pregnancy on neurodevelopment. Higher maternal dietary intake of phylloquinone was associated with higher global developmental index scores, as well as improved cognitive and physical development in early childhood. These findings emphasize the need for tailored vitamin K recommendations during pregnancy to support optimal brain development in offspring.
Filiaciones:
Mateu-Fabregat J:
Nutrition and Metabolic Health Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili (URV), Reus, Spain
Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain
Center of Environmental, Food and Toxicological Technology (TecnATox), Universitat Rovira i Virgili (URV), Reus, Spain
Panisello L:
Nutrition and Metabolic Health Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili (URV), Reus, Spain
Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain
Center of Environmental, Food and Toxicological Technology (TecnATox), Universitat Rovira i Virgili (URV), Reus, Spain
Novau-Ferré N:
Nutrition and Metabolic Health Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili (URV), Reus, Spain
Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain
Center of Environmental, Food and Toxicological Technology (TecnATox), Universitat Rovira i Virgili (URV), Reus, Spain
Pinar-Martí A:
Clinical and Epidemiological Neuroscience (NeuroÈ?pia), Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
CIBER de Epidemiología y Salud Pública (CIBERESP), Carlos III Health Institute, Madrid, Spain
Jimenez-Arenas P:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
CIBER de Epidemiología y Salud Pública (CIBERESP), Carlos III Health Institute, Madrid, Spain
Ferrer M:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
CIBER de Epidemiología y Salud Pública (CIBERESP), Carlos III Health Institute, Madrid, Spain
Rivas I:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
CIBER de Epidemiología y Salud Pública (CIBERESP), Carlos III Health Institute, Madrid, Spain
Institute of Environmental Assessment and Water Research (IDAEA), Spanish National Research Council (CSIC), Barcelona, Spain
Llurba E:
Department of Obstetrics and Gynaecology. Institut d'Investigació Biomèdica Sant Pau-IIB Sant Pau. Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Lassale C:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
CIBER Physiology of Obesity and Nutrition (CIBEROBN), Carlos III Health Institute, Madrid, Spain
Gómez-Roig MD:
BCNatal. Barcelona Center for Maternal Fetal and Neonatal Medicine (Hospital Sant Joan de Déu and Hospital Clínic), University of Barcelona, Barcelona, Spain
Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain
Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin Network (RICORS), RD21/0012/0003, Instituto de Salud Carlos III, Madrid, Spain
Vioque J:
CIBER de Epidemiología y Salud Pública (CIBERESP), Carlos III Health Institute, Madrid, Spain
Universidad Miguel Hernández, Instituto de Investigación Sanitaria y Biomédica de Alicante (UMH-ISABIAL), Alicante, Spain
González-Palacios S:
CIBER de Epidemiología y Salud Pública (CIBERESP), Carlos III Health Institute, Madrid, Spain
Universidad Miguel Hernández, Instituto de Investigación Sanitaria y Biomédica de Alicante (UMH-ISABIAL), Alicante, Spain
Contreras-Rodríguez O:
Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain
CIBER Mental Health (CIBERSAM), Carlos III Health Institute, Madrid, Spain
Arija V:
Nutrition and Mental Health Research Group (NUTRISAM), Universitat Rovira i Virgili (URV), Tarragona, Spain
Foraster M:
PHAGEX Research Group, Blanquerna School of Health Science, Universitat Ramon Llull (URL), Barcelona, Spain
Gascon M:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
CIBER de Epidemiología y Salud Pública (CIBERESP), Carlos III Health Institute, Madrid, Spain
Unitat de Suport a la Recerca de la Catalunya Central, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Manresa, Spain
Dadvand P:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
CIBER de Epidemiología y Salud Pública (CIBERESP), Carlos III Health Institute, Madrid, Spain
Sunyer J:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
CIBER de Epidemiología y Salud Pública (CIBERESP), Carlos III Health Institute, Madrid, Spain
Júlvez J:
Clinical and Epidemiological Neuroscience (NeuroÈ?pia), Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
CIBER de Epidemiología y Salud Pública (CIBERESP), Carlos III Health Institute, Madrid, Spain
Bulló M:
Nutrition and Metabolic Health Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili (URV), Reus, Spain
Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain
Center of Environmental, Food and Toxicological Technology (TecnATox), Universitat Rovira i Virgili (URV), Reus, Spain
CIBER Physiology of Obesity and Nutrition (CIBEROBN), Carlos III Health Institute, Madrid, Spain
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