Assessing SICI Cortical Inhibition With DLPFC TMS-EEG Using Different ISI Values
Por:
Mijancos-Martínez G, Bachiller A, Fernández-Linsenbarth I, Ruiz-Gómez SJ, Romero S, Molina V and Mañanas MA
Publicada:
1 ene 2026
Resumen:
The evaluation of cortical inhibition (CI) in dorsolateral prefrontal cortex (DLPFC) using transcranial magnetic stimulation combined with electroencephalography (TMS-EEG) has focused great attention in recent years. One of the most common procedures to assess such inhibition is the short-interval cortical inhibition (SICI), a paired-pulse paradigm defined by the interstimulus interval (ISI). While SICI was initially defined and extensively used in studies targeting the motor cortex, its application to the DLPFC is relatively recent. However, little is known about how ISI values affect the DLFPC, especially in terms of the TMS-evoked potentials (TEP). This study aims to quantitatively compare the effects of different ISI values in the SICI protocol on CI in the DLPFC by assessing TEPs. Eighteen healthy subjects underwent the SICI protocol using two different ISIs: 2 ms and 4 ms. TMS-EEG responses for both ISIs were characterized in terms of amplitude, latency, peak-to-peak amplitudes, and the area under the rectified curve of the TEPs. The results indicate that TEPs differed depending on the ISI used, finding a significantly greater inhibition with 2 ms ISI, as reflected by a more pronounced reduction in TEP amplitude. These findings are consistent with previous literature on motor cortex stimulation, suggesting that a greater reduction in TEP, and hence greater inhibition, is likely achieved with a 2 ms ISI. Therefore, the study helps in the standardization of SICI protocol in DLFPC.
Filiaciones:
Mijancos-Martínez G:
Automatic Control Department (ESAII) and Institute for Research and Innovation in Health (IRIS), Universitat Politècnica de Catalunya - BarcelonaTech (UPC), Barcelona, Spain
Institute of Research Sant Joan de Déu, Barcelona, Spain
Bachiller A:
Automatic Control Department (ESAII) and Institute for Research and Innovation in Health (IRIS), Universitat Politècnica de Catalunya - BarcelonaTech (UPC), Barcelona, Spain
Institute of Research Sant Joan de Déu, Barcelona, Spain
Fernández-Linsenbarth I:
Psychiatry Department, School of Medicine, University of Valladolid, Valladolid, Spain
Ruiz-Gómez SJ:
Automatic Control Department (ESAII) and Institute for Research and Innovation in Health (IRIS), Universitat Politècnica de Catalunya - BarcelonaTech (UPC), Barcelona, Spain
Institute of Research Sant Joan de Déu, Barcelona, Spain
Romero S:
Automatic Control Department (ESAII) and Institute for Research and Innovation in Health (IRIS), Universitat Politècnica de Catalunya - BarcelonaTech (UPC), Barcelona, Spain
Institute of Research Sant Joan de Déu, Barcelona, Spain
CIBER of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain
Molina V:
Psychiatry Department, School of Medicine, University of Valladolid, Valladolid, Spain
Psychiatry Service, Clinical Hospital of Valladolid, Valladolid, Spain
Neurosciences Institute of Castilla y Léon (INCYL), University of Salamanca, Salamanca, Spain
Mañanas MA:
Automatic Control Department (ESAII) and Institute for Research and Innovation in Health (IRIS), Universitat Politècnica de Catalunya - BarcelonaTech (UPC), Barcelona, Spain
Institute of Research Sant Joan de Déu, Barcelona, Spain
CIBER of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain
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