Real-world effectiveness and tolerability of highly purified cannabidiol in patients with monogenic developmental and epileptic encephalopathies with highly active epilepsy

Por: Irelli, EC, Mazzeo, A, Caraballo, RH, Perulli, M, Moloney, PB, Peña-Ceballos, J, Simeone, N, Mieszczanek, TS, Marini, L, Licchetta, L, De Giorgis, V, Valenzuel, GR, Casellato, S, Cesaroni, E, Operto, FF, Domínguez-Carral J, Camacho-Saez AM, Ferretti, A, Santangelo, G, Aledo-Serrano, A, Rüegger, A, Mancardi, MM, Prato, G, Riva, A, Bergonzini, L, Cordelli, DM, Bonanni, P, Bisulli, F, Di Gennaro, G, Matricardi, S, Striano, P, Delantye, N, Marini, C, Battaglia, DI, Di Bonaventura, C, Ramantani, G and Gardella, E

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Publicada: 1 jul 2026 Ahead of Print: 1 abr 2026

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Filiaciones:
Irelli, EC:
 Sapienza Univ, Dept Human Neurosci, Rome, Italy

Mazzeo, A:
 Sapienza Univ, Dept Human Neurosci, Rome, Italy

Caraballo, RH:
 Hosp Pediat Prof Dr Juan P Garrahan, Dept Neurol, Buenos Aires, Argentina

Perulli, M:
 Fdn Policlin Univ Agostino Gemelli IRCCS, Pediat Neurol & Psychiat Unit, Rome, Italy

Moloney, PB:
 Mater Misericordiae Univ Hosp, Dept Neurol, Dublin, Ireland

Peña-Ceballos, J:
 Beaumont Hosp, Dept Neurol, Dublin, Ireland

Simeone, N:
 Federico II Univ Naples, Dept Neurosci Reprod Sci & Odontostomatol, Naples, Italy

Mieszczanek, TS:
 Danish Epilepsy Ctr, European Reference Network ERN Rare & Complex Epil, Dianalund, Denmark

Marini, L:
 Univ Pisa, Dept Clin & Expt Med, I-56100 Pisa, Italy

Licchetta, L:
 IRCCS Ist Sci Neurolog Bologna, European Reference Network ERN Rare & Complex Epil, Bologna, Italy

De Giorgis, V:
 Univ Pavia, Brain & Behav Sci Dept, Pavia, Italy

 IRCCS Mondino Fdn, ERN EpiCARE, Childhood & Adolescence Epilepsy Ctr, Dept Child Neurol & Psychiat, Pavia, Italy

Valenzuel, GR:
 Hosp Pediat Prof Dr Juan P Garrahan, Dept Neurol, Buenos Aires, Argentina

Casellato, S:
 Univ Sassari, Ctr Pediat Epilepsies, Dept Womans & Childs Hlth, Child Neuropsichiatry Unit, Sassari, Italy

Cesaroni, E:
 Azienda Osped Univ Marche, Pediat Hosp G Salesi, Child Neurol & Psychiat Unit, Ancona, Italy

Operto, FF:
 Univ Catanzaro, Sch Med, Dept Sci Hlth, Catanzaro, Italy

Domínguez-Carral J:
 Inst Recerca St Joan Deu, Dept Child Neurol, Epilepsy Unit, European Reference Network ERN Rare & Complex Epil, Barcelona, Spain

Camacho-Saez AM:
 Inst Recerca St Joan Deu, Dept Child Neurol, Epilepsy Unit, European Reference Network ERN Rare & Complex Epil, Barcelona, Spain

Ferretti, A:
 St Andrea Hosp, Fac Med & Psychol, Dept Neurosci Mental Hlth & Sense Organs NESMOS, I-00198 Rome, Italy

Santangelo, G:
 ISMEP ARNAS Civico, Child Neuropsychiat Dept, I-90100 Palermo, Italy

Aledo-Serrano, A:
 Blua Sanitas Valdebebas Hosp, Clin Neurosci Dept, Epilepsy Unit, Madrid, Spain

Rüegger, A:
 Univ Childrens Hosp Zurich, Dept Neuropediat, Zurich, Switzerland

Mancardi, MM:
 IRCCS Ist Giannina Gaslini, European Reference Network ERN Rare & Complex Epil, Genoa, Italy

Prato, G:
 IRCCS Ist Giannina Gaslini, European Reference Network ERN Rare & Complex Epil, Genoa, Italy

Riva, A:
 Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet Maternal &, Genoa, Italy

Bergonzini, L:
 IRCCS Ist Sci Neurolog Bologna, European Reference Network ERN Rare & Complex Epil, Bologna, Italy

 Alma Mater Studiorum Univ Bologna, Dept Med & Surg Sci DIMEC, Bologna, Italy

Cordelli, DM:
 IRCCS Ist Sci Neurolog Bologna, European Reference Network ERN Rare & Complex Epil, Bologna, Italy

 Alma Mater Studiorum Univ Bologna, Dept Med & Surg Sci DIMEC, Bologna, Italy

Bonanni, P:
 Sci Inst IRCCS E Medea, Epilepsy & Clin Neurophysiol Unit, I-31015 Conegliano, Italy

Bisulli, F:
 IRCCS Ist Sci Neurolog Bologna, European Reference Network ERN Rare & Complex Epil, Bologna, Italy

 Univ Bologna, Dept Biomed & Neuromotor Sci, Bologna, Italy

Di Gennaro, G:
 IRCCS Neuromed, I-86077 Isernia, Italy

Matricardi, S:
 Univ G dAnnunzio, Dept Pediat, I-66100 Chieti, Italy

Striano, P:
 IRCCS Ist Giannina Gaslini, European Reference Network ERN Rare & Complex Epil, Genoa, Italy

 Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet Maternal &, Genoa, Italy

Delantye, N:
 Beaumont Hosp, Dept Neurol, Dublin, Ireland

 Royal Coll Surgeons Ireland, Sch Pharm & Biomol Sci, Dublin, Ireland

 Res Ireland FutureNeuro Ctr, Dublin, Ireland

Marini, C:
 Azienda Osped Univ Marche, Pediat Hosp G Salesi, Child Neurol & Psychiat Unit, Ancona, Italy

Battaglia, DI:
 Fdn Policlin Univ Agostino Gemelli IRCCS, Pediat Neurol & Psychiat Unit, Rome, Italy

Di Bonaventura, C:
 Sapienza Univ, Dept Human Neurosci, Rome, Italy

Ramantani, G:
 Univ Childrens Hosp Zurich, Dept Neuropediat, Zurich, Switzerland

Gardella, E:
 Danish Epilepsy Ctr, European Reference Network ERN Rare & Complex Epil, Dianalund, Denmark

 Univ Southern Denmark, Odense, Denmark