Prenatal growth restraint followed by catch-up of weight:: a hyperinsulinemic pathway to polycystic ovary syndrome
Por:
de Zegher F and Ibañez-Toda L
Publicada:
1 jul 2006
Resumen:
One of the pathways to polycystic ovary syndrome (PCOS) starts with an early-life sequence of prenatal growth restraint followed by catch-up of weight during infancy. This sequence results by mid-childhood in a pre-PCOS state including hyperinsulinemia, a low-grade proinflammatory state, an amplified adrenarche (with or without precocious pubarche) and an adipose body composition even in the absence of obesity. This variant of pre-PCOS and PCOS responds well to intervention with metformin.
Filiaciones:
de Zegher F:
Department of Woman and Child, University of Leuven, Leuven, Belgium
Ibañez-Toda L:
Department of Woman and Child, University of Leuven, Leuven, Belgium
Univ Barcelona, Hosp St Joan Deu, Endocrinol Unit, Barcelona 08950, Spain.
Katholieke Univ Leuven, Dept Woman & Child, Louvain, Belgium
Univ Barcelona, Hosp St Joan Deu, Endocrinol Unit, Barcelona 08950, Spain
Katholieke Univ Leuven, Dept Woman & Child, Louvain, Belgium
Univ Barcelona, Hosp St Joan Deu, Endocrinol Unit, Barcelona 08950, Spain
Katholieke Univ Leuven, Dept Woman & Child, Louvain, Belgium
Bronze
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