Natural history, outcome, and treatment efficacy in children and adults with glutaryl-CoA dehydrogenase deficiency
Por:
Kölker S, Garbade SF, Greenberg CR, Leonard JV, Saudubray JM, Ribes A, Kalkanoglu HS, Lund AM, Merinero B, Wajner M, Troncoso M, Williams M, Walter JH, Campistol-Plana J, Martí-Herrero M, Caswill M, Burlina AB, Lagler F, Maier EM, Schwahn B, Tokatli A, Dursun A, Coskun T, Chalmers RA, Koeller DM, Zschocke J, Christensen E, Burgard P and Hoffmann GF
Publicada:
1 jun 2006
Ahead of Print:
26 abr 2006
Categoría:
Pediatrics, Perinatology and Child Health
Resumen:
Glutaryl-CoA dehydrogenase (GCDH) deficiency is a rare inborn disorder of L-lysine, L-hydroxylysine, and L-tryptophan metabolism complicated by striatal damage during acute encephalopathic crises. Three decades after its description, the natural history and how to treat this disorder are still incompletely understood. To study which variables influenced the outcome, we conducted an international cross-sectional study in 35 metabolic centers. Our main outcome measures were onset and neurologic sequelae of acute encephalopathic crises. A total of 279 patients (160 male, 119 female) were included who were diagnosed clinically after clinical presentation (n = 218) or presymptomatically by neonatal screening (n = 23), high-risk screening (n = 24), or macrocephaly (n = 14). Most symptomatic patients (n = 185) had encephalopathic crises, characteristically resulting in bilateral striatal damage and dystonia, secondary complications, and reduced life expectancy. First crises usually occurred during infancy (95% by age 2 y); the oldest age at which a repeat crisis was reported was 70 mo. In a few patients, neurologic disease developed without a reported crisis. Differences in the diagnostic criteria and therapeutic protocols for patients with GCDH deficiency resulted in a huge variability in the outcome worldwide. Recursive partitioning demonstrated that timely diagnosis in neurologically asymptomatic patients followed by treatment with L-carnitine and a lysine-restricted diet was the best predictor of good outcome, whereas treatment efficacy was low in patients diagnosed after the onset of neurologic disease. Notably, the biochemical phenotype did not predict the clinical phenotype. Our study proves GCDH deficiency to be a treatable disorder and a good candidate for neonatal screening.
Filiaciones:
Kölker S:
Department of General Pediatric, University of Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.
Garbade SF:
Department of General Pediatric, University of Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.
Greenberg CR:
Department of General Pediatric, University of Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.
Leonard JV:
Department of General Pediatric, University of Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.
Saudubray JM:
Department of General Pediatric, University of Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.
Ribes A:
Department of General Pediatric, University of Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.
Kalkanoglu HS:
Department of General Pediatric, University of Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.
Lund AM:
Department of General Pediatric, University of Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.
Merinero B:
Department of General Pediatric, University of Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.
Wajner M:
Department of General Pediatric, University of Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.
Troncoso M:
Department of General Pediatric, University of Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.
Williams M:
Department of General Pediatric, University of Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.
Walter JH:
Department of General Pediatric, University of Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.
Campistol-Plana J:
Department of General Pediatric, University of Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.
Martí-Herrero M:
Department of General Pediatric, University of Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.
Caswill M:
Department of General Pediatric, University of Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.
Burlina AB:
Department of General Pediatric, University of Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.
Lagler F:
Department of General Pediatric, University of Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.
Maier EM:
Department of General Pediatric, University of Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.
Schwahn B:
Department of General Pediatric, University of Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.
Tokatli A:
Department of General Pediatric, University of Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.
Dursun A:
Department of General Pediatric, University of Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.
Coskun T:
Department of General Pediatric, University of Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.
Chalmers RA:
Department of General Pediatric, University of Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.
Koeller DM:
Department of General Pediatric, University of Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.
Zschocke J:
Department of General Pediatric, University of Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.
Christensen E:
Department of General Pediatric, University of Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.
Burgard P:
Department of General Pediatric, University of Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.
Hoffmann GF:
Department of General Pediatric, University of Children's Hospital Heidelberg, D-69120 Heidelberg, Germany.
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