Levels and patterns of HIV RNA viral load in untreated pregnant women
Por:
Patel, Deven, Thorne, Claire, Newell, Marie-Louise, Cortina-Borja, Mario, Giaquinto, C., Rampon, O., D'Elia, R., De Rossi, A., Grosch-Woerner, I., Mok, J., de Jose, M. I., Martinez, B. Larru, Pena, J. M., Gonzalez Garcia, J, Arribas Lopez, J. R., Garcia-Rodriguez, J., Asensi-Botet, F., Otero, M. C., Perez-Tamarit, D., Scherpbier, H. J., Kreyenbroek, M., Godfried, M. H., Nellen, F. J. B., Boer, K., Ehrnst, A., Bohlin, A. B., Lindgren, S., Anzen, B., Lidman, K., Levy, J., Barlow, P., Manigart, Y., Hainaut, M., Goetghebuer, T., Ferrazin, A., Viscoli, C., De Maria, A., Bentivoglio, G., Ferrero, S., Gotta, C., Mur, A., Paya, A., Lopez-Vilchez, M. A., Carreras, R., Valerius, N. H., Rosenfeldt, V., Jimenez, J., Coll, O., Suy, A., Perez, J. M., Fortuny-Guasch C, Boguña-Ponsa JM, Casellas Caro, M., Canet, Y., Ravizza, M., Guerra, B., Lanari, M., Bianchi, S., Bovicelli, L., Prati, E., Duse, M., Scaravelli, G., Stegagno, M., De Santis, M., Savasi, V., Fiore, S., Crivelli, M., Ferrazzi, E., Vigano, A., Giacomet, V., Cerini, C., Raimondi, C., Zuccotti, G., Probizer, F. R., Maccabruni, A., Bucceri, A., Rancilio, L., Alberico, S., Rabusin, M., Bernardon, M., Taylor, G. P., Lyall, E. G. H., Penn, Z., Buffolano, W., Tiseo, R., Martinelli, A., Sansone, M., Maruotti, G., Agangi, A., Tibaldi, C., Marini, S., Masuelli, G., Benedetto, C., Niemiec, T., Marczynska, M., Dobosz, S., Popielska, J., Oldakowska, A., Malyuta, R., Semenenko, I., Pilipenko, T., Posokhova, S., Kaleeva, T., Stelmah, A., Kiseleva, G. and European Collaborative Study
Publicada:
1 mar 2009
Resumen:
Objective: To assess pregnancy levels and patterns of HIV RNA in the absence of antiretroviral therapy, while appropriately adjusting for potential confounders, including maternal immune status and race.
Methods: Data on >= 1 antenatal HIV RNA measurements were available for 333 untreated HIV-infected pregnant women enrolled in the European Collaborative Study. CD4 counts and HIV RNA measurements were routinely collected from 1992 and 1998, respectively. Linear mixed effects models based on 246 women for whom complete data were available examined changes in HIV RNA levels over pregnancy, with a nested random effects term accounting for measurement variability within women and period of sample collection.
Results: The change in HIV RNA over pregnancy varied significantly by race (p = 0.005): from the second trimester until delivery, HIV RNA decreased significantly by an estimated 0.019 log(10) copies/ml/week in white women (95% Cl -0.03, -0.007); in black women the estimated 0.016 log(10) copies/ml/week increase (95% Cl -0.005, 0.037) was not statistically significant. At delivery, HIV RNA levels in black women were 0.45 log(10) copies/ml higher (95% Cl 0.08, 0.83) than in white women.
Conclusions: Our findings suggest that HIV RNA dynamics over pregnancy differ by race, although other interpretations cannot be excluded, due to potential for unmeasured confounding. (C) 2008 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
Filiaciones:
Thorne, Claire:
UCL, Inst Child Hlth, Ctr Paediat Epidemiol & Biostat, London WC1N 1EH, England
Giaquinto, C.:
Univ Degli Studi Padova, Padua, Italy
Rampon, O.:
Univ Degli Studi Padova, Padua, Italy
D'Elia, R.:
Univ Degli Studi Padova, Padua, Italy
De Rossi, A.:
Univ Degli Studi Padova, Padua, Italy
Grosch-Woerner, I.:
Charite Virchow Klinikum, Berlin, Germany
Mok, J.:
Royal Hosp Sick Children, Edinburgh, Midlothian, Scotland
de Jose, M. I.:
Hosp Infantil La Paz, Madrid, Spain
Martinez, B. Larru:
Hosp Infantil La Paz, Madrid, Spain
Pena, J. M.:
Hosp Infantil La Paz, Madrid, Spain
Gonzalez Garcia, J:
Hosp Infantil La Paz, Madrid, Spain
Arribas Lopez, J. R.:
Hosp Infantil La Paz, Madrid, Spain
Garcia-Rodriguez, J.:
Hosp Infantil La Paz, Madrid, Spain
Asensi-Botet, F.:
Hosp La Fe, Valencia, Spain
Otero, M. C.:
Hosp La Fe, Valencia, Spain
Perez-Tamarit, D.:
Hosp La Fe, Valencia, Spain
Scherpbier, H. J.:
Acad Med Centrum, Amsterdam, Netherlands
Kreyenbroek, M.:
Acad Med Centrum, Amsterdam, Netherlands
Godfried, M. H.:
Acad Med Centrum, Amsterdam, Netherlands
Nellen, F. J. B.:
Acad Med Centrum, Amsterdam, Netherlands
Boer, K.:
Acad Med Centrum, Amsterdam, Netherlands
Ehrnst, A.:
Karolinska Univ Hosp, Huddinge, Sweden
Karolinska Univ Hosp, Solna, Sweden
Bohlin, A. B.:
Karolinska Univ Hosp, Huddinge, Sweden
Karolinska Univ Hosp, Solna, Sweden
Lindgren, S.:
Karolinska Univ Hosp, Huddinge, Sweden
Karolinska Univ Hosp, Solna, Sweden
Anzen, B.:
Karolinska Univ Hosp, Huddinge, Sweden
Karolinska Univ Hosp, Solna, Sweden
Lidman, K.:
Karolinska Univ Hosp, Huddinge, Sweden
Karolinska Univ Hosp, Solna, Sweden
Levy, J.:
Hosp St Pierre, Brussels, Belgium
Barlow, P.:
Hosp St Pierre, Brussels, Belgium
Manigart, Y.:
Hosp St Pierre, Brussels, Belgium
Hainaut, M.:
Hosp St Pierre, Brussels, Belgium
Goetghebuer, T.:
Hosp St Pierre, Brussels, Belgium
Ferrazin, A.:
Univ Genoa, Infect Dis Clin, Genoa, Italy
Viscoli, C.:
Univ Genoa, Infect Dis Clin, Genoa, Italy
De Maria, A.:
Univ Genoa, Dept Internal Med, Genoa, Italy
Bentivoglio, G.:
Univ Genoa, Dept Obstet & Gynecol, Neonatol Unit, Genoa, Italy
Ferrero, S.:
Univ Genoa, Dept Obstet & Gynecol, Neonatol Unit, Genoa, Italy
Gotta, C.:
Univ Genoa, Dept Obstet & Gynecol, Neonatol Unit, Genoa, Italy
Mur, A.:
Univ Autonoma Barcelona, Hosp Mar, Barcelona, Spain
Paya, A.:
Univ Autonoma Barcelona, Hosp Mar, Barcelona, Spain
Lopez-Vilchez, M. A.:
Univ Autonoma Barcelona, Hosp Mar, Barcelona, Spain
Carreras, R.:
Univ Autonoma Barcelona, Hosp Mar, Barcelona, Spain
Valerius, N. H.:
Hvidovre Univ Hosp, Hvidovre, Denmark
Rosenfeldt, V.:
Hvidovre Univ Hosp, Hvidovre, Denmark
Jimenez, J.:
Hosp 12 Octubre, Madrid, Spain
Coll, O.:
Hosp Clin Barcelona, Barcelona, Spain
Suy, A.:
Hosp Clin Barcelona, Barcelona, Spain
Perez, J. M.:
Hosp Clin Barcelona, Barcelona, Spain
Fortuny-Guasch C:
Hosp San Juan Dios, Barcelona, Spain
Boguña-Ponsa JM:
Hosp San Juan Dios, Barcelona, Spain
Casellas Caro, M.:
Hosp Gen Valle Hebron, Barcelona, Spain
Canet, Y.:
Hosp Parc Tauli De Sabadell, Barcelona, Spain
Ravizza, M.:
Osped San Paolo, Milan, Italy
Guerra, B.:
Policlin S Orsola, Bologna, Italy
Lanari, M.:
Policlin S Orsola, Bologna, Italy
Bianchi, S.:
Policlin S Orsola, Bologna, Italy
Bovicelli, L.:
Policlin S Orsola, Bologna, Italy
Prati, E.:
Univ Brescia, Brescia, Italy
Duse, M.:
Univ Brescia, Brescia, Italy
Scaravelli, G.:
Univ Roma La Sapienza, Rome, Italy
Stegagno, M.:
Univ Roma La Sapienza, Rome, Italy
De Santis, M.:
Univ Cattolica, Rome, Italy
Savasi, V.:
Osped L Sacco, Milan, Italy
Fiore, S.:
Osped L Sacco, Milan, Italy
Crivelli, M.:
Osped L Sacco, Milan, Italy
Ferrazzi, E.:
Osped L Sacco, Milan, Italy
Vigano, A.:
Univ Milan, L Sacco Hosp, Milan, Italy
Giacomet, V.:
Univ Milan, L Sacco Hosp, Milan, Italy
Cerini, C.:
Policlin San Matteo, Pavia, Italy
Raimondi, C.:
Univ Milan, L Sacco Hosp, Milan, Italy
Zuccotti, G.:
Univ Milan, L Sacco Hosp, Milan, Italy
Probizer, F. R.:
Policlin San Matteo, Pavia, Italy
Maccabruni, A.:
Policlin San Matteo, Pavia, Italy
Bucceri, A.:
Clin Mangiagalli, Milan, Italy
Clin De Marchi, Milan, Italy
Rancilio, L.:
Clin Mangiagalli, Milan, Italy
Clin De Marchi, Milan, Italy
Alberico, S.:
IRCCS Burlo Garofolo, Trieste, Italy
Rabusin, M.:
IRCCS Burlo Garofolo, Trieste, Italy
Bernardon, M.:
IRCCS Burlo Garofolo, Trieste, Italy
Taylor, G. P.:
St Marys Hosp, London, England
Lyall, E. G. H.:
St Marys Hosp, London, England
Penn, Z.:
Chelsea Hosp, London, England
Westminster Med Sch & Hosp, London, England
Buffolano, W.:
Univ Naples Federico 2, Dept Pediat, Naples, Italy
Tiseo, R.:
Univ Naples Federico 2, Dept Pediat, Naples, Italy
Martinelli, A.:
Univ Naples Federico 2, Dept Obstet, Naples, Italy
Sansone, M.:
Univ Naples Federico 2, Dept Obstet, Naples, Italy
Maruotti, G.:
Univ Naples Federico 2, Dept Obstet, Naples, Italy
Agangi, A.:
Univ Naples Federico 2, Dept Obstet, Naples, Italy
Tibaldi, C.:
Univ Turin, Turin, Italy
Marini, S.:
Univ Turin, Turin, Italy
Masuelli, G.:
Univ Turin, Turin, Italy
Benedetto, C.:
Univ Turin, Turin, Italy
Niemiec, T.:
Natl Res Inst Mother & Child, Warsaw, Poland
Marczynska, M.:
Med Univ Warsaw, Infect Dis Hosp, Warsaw, Poland
Dobosz, S.:
Med Univ Warsaw, Infect Dis Hosp, Warsaw, Poland
Popielska, J.:
Med Univ Warsaw, Infect Dis Hosp, Warsaw, Poland
Oldakowska, A.:
Med Univ Warsaw, Infect Dis Hosp, Warsaw, Poland
Green Submitted, gold
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