Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
Por:
Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V, Abraham J, Ackerman I, Aggarwal R, Ahn SY, Ali MK, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Bahalim AN, Barker-Collo S, Barrero LH, Bartels DH, Basáñez MG, Baxter A, Bell ML, Benjamin EJ, Bennett D, Bernabé E, Bhalla K, Bhandari B, Bikbov B, Bin Abdulhak A, Birbeck G, Black JA, Blencowe H, Blore JD, Blyth F, Bolliger I, Bonaventure A, Boufous S, Bourne R, Boussinesq M, Braithwaite T, Brayne C, Bridgett L, Brooker S, Brooks P, Brugha TS, Bryan-Hancock C, Bucello C, Buchbinder R, Buckle G, Budke CM, Burch M, Burney P, Burstein R, Calabria B, Campbell B, Canter CE, Carabin H, Carapetis J, Carmona L, Cella C, Charlson F, Chen H, Cheng AT, Chou D, Chugh SS, Coffeng LE, Colan SD, Colquhoun S, Colson KE, Condon J, Connor MD, Cooper LT, Corriere M, Cortinovis M, de Vaccaro KC, Couser W, Cowie BC, Criqui MH, Cross M, Dabhadkar KC, Dahiya M, Dahodwala N, Damsere-Derry J, Danaei G, Davis A, De Leo D, Degenhardt L, Dellavalle R, Delossantos A, Denenberg J, Derrett S, Des Jarlais DC, Dharmaratne SD, Dherani M, Diaz-Torne C, Dolk H, Dorsey ER, Driscoll T, Duber H, Ebel B, Edmond K, Elbaz A, Ali SE, Erskine H, Erwin PJ, Espindola P, Ewoigbokhan SE, Farzadfar F, Feigin V, Felson DT, Ferrari A, Ferri CP, Fèvre EM, Finucane MM, Flaxman S, Flood L, Foreman K, Forouzanfar MH, Fowkes FG, Franklin R, Fransen M, Freeman MK, Gabbe BJ, Gabriel SE, Gakidou E, Ganatra HA, Garcia B, Gaspari F, Gillum RF, Gmel G, Gosselin R, Grainger R, Groeger J, Guillemin F, Gunnell D, Gupta R, Haagsma J, Hagan H, Halasa YA, Hall W, Haring D, Haro JM, Harrison JE, Havmoeller R, Hay RJ, Higashi H, Hill C, Hoen B, Hoffman H, Hotez PJ, Hoy D, Huang JJ, Ibeanusi SE, Jacobsen KH, James SL, Jarvis D, Jasrasaria R, Jayaraman S, Johns N, Jonas JB, Karthikeyan G, Kassebaum N, Kawakami N, Keren A, Khoo JP, King CH, Knowlton LM, Kobusingye O, Koranteng A, Krishnamurthi R, Lalloo R, Laslett LL, Lathlean T, Leasher JL, Lee YY, Leigh J, Lim SS, Limb E, Lin JK, Lipnick M, Lipshultz SE, Liu W, Loane M, Ohno SL, Lyons R, Ma J, Mabweijano J, MacIntyre MF, Malekzadeh R, Mallinger L, Manivannan S, Marcenes W, March L, Margolis DJ, Marks GB, Marks R, Matsumori A, Matzopoulos R, Mayosi BM, McAnulty JH, McDermott MM, McGill N, McGrath J, Medina-Mora ME, Meltzer M, Mensah GA, Merriman TR, Meyer AC, Miglioli V, Miller M, Miller TR, Mitchell PB, Mocumbi AO, Moffitt TE, Mokdad AA, Monasta L, Montico M, Moradi-Lakeh M, Moran A, Morawska L, Mori R, Murdoch ME, Mwaniki MK, Naidoo K, Nair MN, Naldi L, Narayan KM, Nelson PK, Nelson RG, Nevitt MC, Newton CR, Nolte S, Norman P, Norman R, O'Donnell M, O'Hanlon S, Olives C, Omer SB, Ortblad K, Osborne R, Ozgediz D, Page A, Pahari B, Pandian JD, Rivero AP, Patten SB, Pearce N, Padilla RP, Perez-Ruiz F, Perico N, Pesudovs K, Phillips D, Phillips MR, Pierce K, Pion S, Polanczyk GV, Polinder S, Pope CA, Popova S, Porrini E, Pourmalek F, Prince M, Pullan RL, Ramaiah KD, Ranganathan D, Razavi H, Regan M, Rehm JT, Rein DB, Remuzzi G, Richardson K, Rivara FP, Roberts T, Robinson C, De Leòn FR, Ronfani L, Room R, Rosenfeld LC, Rushton L, Sacco RL, Saha S, Sampson U, Sanchez-Riera L, Sanman E, Schwebel DC, Scott JG, Segui-Gomez M, Shahraz S, Shepard DS, Shin H, Shivakoti R, Singh D, Singh GM, Singh JA, Singleton J, Sleet DA, Sliwa K, Smith E, Smith JL, Stapelberg NJ, Steer A, Steiner T, Stolk WA, Stovner LJ, Sudfeld C, Syed S, Tamburlini G, Tavakkoli M, Taylor HR, Taylor JA, Taylor WJ, Thomas B, Thomson WM, Thurston GD, Tleyjeh IM, Tonelli M, Towbin JA, Truelsen T, Tsilimbaris MK, Ubeda C, Undurraga EA, van der Werf MJ, van Os J, Vavilala MS, Venketasubramanian N, Wang M, Wang W, Watt K, Weatherall DJ, Weinstock MA, Weintraub R, Weisskopf MG, Weissman MM, White RA, Whiteford H, Wiersma ST, Wilkinson JD, Williams HC, Williams SR, Witt E, Wolfe F, Woolf AD, Wulf S, Yeh PH, Zaidi AK, Zheng ZJ, Zonies D, Lopez AD, Murray CJ, AlMazroa MA and Memish ZA
Publicada:
15 dic 2012
Categoría:
Medicine (miscellaneous)
Resumen:
Background Non-fatal health outcomes from diseases and injuries are a
crucial consideration in the promotion and monitoring of individual and
population health. The Global Burden of Disease (GBD) studies done in
1990 and 2000 have been the only studies to quantify non-fatal health
outcomes across an exhaustive set of disorders at the global and
regional level. Neither effort quantified uncertainty in prevalence or
years lived with disability (YLDs).
Methods Of the 291 diseases and injuries in the GBD cause list, 289
cause disability. For 1160 sequelae of the 289 diseases and injuries, we
undertook a systematic analysis of prevalence, incidence, remission,
duration, and excess mortality. Sources included published studies, case
notification, population-based cancer registries, other disease
registries, antenatal clinic serosurveillance, hospital discharge data,
ambulatory care data, household surveys, other surveys, and cohort
studies. For most sequelae, we used a Bayesian meta-regression method,
DisMod-MR, designed to address key limitations in descriptive
epidemiological data, including missing data, inconsistency, and large
methodological variation between data sources. For some disorders, we
used natural history models, geospatial models, back-calculation models
(models calculating incidence from population mortality rates and case
fatality), or registration completeness models (models adjusting for
incomplete registration with health-system access and other covariates).
Disability weights for 220 unique health states were used to capture the
severity of health loss. YLDs by cause at age, sex, country, and year
levels were adjusted for comorbidity with simulation methods. We
included uncertainty estimates at all stages of the analysis.
Findings Global prevalence for all ages combined in 2010 across the 1160
sequelae ranged from fewer than one case per 1 million people to 350 000
cases per 1 million people. Prevalence and severity of health loss were
weakly correlated (correlation coefficient -0.37). In 2010, there were
777 million YLDs from all causes, up from 583 million in 1990. The main
contributors to global YLDs were mental and behavioural disorders,
musculoskeletal disorders, and diabetes or endocrine diseases. The
leading specific causes of YLDs were much the same in 2010 as they were
in 1990: low back pain, major depressive disorder, iron-deficiency
anaemia, neck pain, chronic obstructive pulmonary disease, anxiety
disorders, migraine, diabetes, and falls. Age-specific prevalence of
YLDs increased with age in all regions and has decreased slightly from
1990 to 2010. Regional patterns of the leading causes of YLDs were more
similar compared with years of life lost due to premature mortality.
Neglected tropical diseases, HIV/AIDS, tuberculosis, malaria, and
anaemia were important causes of YLDs in sub-Saharan Africa.
Interpretation Rates of YLDs per 100 000 people have remained largely
constant over time but rise steadily with age. Population growth and
ageing have increased YLD numbers and crude rates over the past two
decades. Prevalences of the most common causes of YLDs, such as mental
and behavioural disorders and musculoskeletal disorders, have not
decreased. Health systems will need to address the needs of the rising
numbers of individuals with a range of disorders that largely cause
disability but not mortality. Quantification of the burden of non-fatal
health outcomes will be crucial to understand how well health systems
are responding to these challenges. Effective and affordable strategies
to deal with this rising burden are an urgent priority for health
systems in most parts of the world.
Open Access
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