HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis

Por: Ombrello MJ, Remmers EF, Tachmazidou I, Grom A, Foell D, Haas JP, Martini A, Gattorno M, Özen S, Prahalad S, Zeft AS, Bohnsack JF, Mellins ED, Ilowite NT, Russo R, Len C, Hilario MO, Oliveira S, Yeung RS, Rosenberg A, Wedderburn LR, Anton-Lopez J, Schwarz T, Hinks A, Bilginer Y, Park J, Cobb J, Satorius CL, Han B, Baskin E, Signa S, Duerr RH, Achkar JP, Kamboh MI, Kaufman KM, Kottyan LC, Pinto D, Scherer SW, Alarcón-Riquelme ME, Docampo E, Estivill X, Gül A, British Society of Pediatric and Adolescent Rheumatology (BSPAR) Study Group, Childhood Arthritis Prospective Study (CAPS) Group, Randomized Placebo Phase Study of Rilonacept in sJIA (RAPPORT) Investigators, Sparks-Childhood Arthritis Response to Medication Study (CHARMS) Group, Biologically Based Outcome Predictors in JIA (BBOP) Group, de Bakker PI, Raychaudhuri S, Langefeld CD, Thompson S, Zeggini E, Thomson W, Kastner DL, Woo P, International Childhood Arthritis Genetics (INCHARGE) Consortium and British Society of Pediatric and Adolescent Rheumatology BSPAR Study Group

---

Publicada: 29 dic 2015 Ahead of Print: 23 nov 2015

---

---

Filiaciones:
Ombrello MJ:
 Translational Genetics and Genomics Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892

 ombrellomj

Remmers EF:
 Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892

Tachmazidou I:
 Human Genetics, The Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, United Kingdom

Grom A:
 Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229

 Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229

Foell D:
 Department of Pediatric Rheumatology and Immunology, University Hospital Münster, D-48149 Münster, Germany

Haas JP:
 German Center for Pediatric and Adolescent Rheumatology, 82467 Garmisch-Partenkirchen, Germany

Martini A:
 Department of Pediatrics, University of Genova, 16145 Genoa, Italy

 Pediatrics II Unit, G. Gaslini Institute, 16147 Genoa, Italy

Gattorno M:
 Pediatrics II Unit, G. Gaslini Institute, 16147 Genoa, Italy

Özen S:
 Department of Pediatric Rheumatology, Hacettepe University, 06100 Ankara, Turkey

Prahalad S:
 Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322

 Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322

Zeft AS:
 Department of Pediatrics, Cleveland Clinic, Cleveland, OH 44195

Bohnsack JF:
 Department of Pediatrics, University of Utah, Salt Lake City, UT 84113

Mellins ED:
 Department of Pediatrics, Stanford University, Stanford, CA 94305

Ilowite NT:
 Department of Pediatrics, Albert Einstein College of Medicine and Children's Hospital at Montefiore, Bronx, NY 10461

Russo R:
 Service of Immunology and Rheumatology, Hospital de Pediatria Garrahan, C1245AAM Buenos Aires, Argentina

Len C:
 Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, 04021-001, Brazil

Hilario MO:
 Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, 04021-001, Brazil

Oliveira S:
 Universidade Federal de Rio de Janeiro, Rio de Janeiro, 21941-901, Brazil

Yeung RS:
 Department of Pediatrics, University of Toronto, Toronto, Canada M5S 1A8

 Department of Immunology, University of Toronto, Toronto, Canada M5S 1A8

 Institute of Medical Science, University of Toronto, Toronto, Canada M5S 1A8

Rosenberg A:
 Department of Pediatrics, University of Saskatchewan, Saskatoon, Canada S7N 0W8

Wedderburn LR:
 Institute of Child Health, University College London, London, WC1N 1EH, United Kingdom

 Center of Paediatric and Adolescent Rheumatology, University College London, London, WC1N 1EH, United Kingdom

Anton-Lopez J:
 Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, 08950 Barcelona, Spain

Schwarz T:
 Section of Pediatric Rheumatology and Osteology, University of Würzberg, 97080 Würzberg, Germany

Hinks A:
 Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT, United Kingdom

Bilginer Y:
 Department of Pediatric Rheumatology, Hacettepe University, 06100 Ankara, Turkey

Park J:
 Department of Pediatrics, Stanford University, Stanford, CA 94305

Cobb J:
 Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT, United Kingdom

 National Institute for Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester National Health Service Foundation Trust, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT, United Kingdom

Satorius CL:
 Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892

Han B:
 Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142

 Division of Immunology, Allergy, and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115

 Department of Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, 138-736, Republic of Korea

Baskin E:
 Translational Genetics and Genomics Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892

Signa S:
 Department of Pediatrics, University of Genova, 16145 Genoa, Italy

Duerr RH:
 Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261

 Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261

Achkar JP:
 Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH 44195

 Department of Pathobiology, Cleveland Clinic, Cleveland, OH 44195

Kamboh MI:
 Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261

Kaufman KM:
 Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229

 Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229

Kottyan LC:
 Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229

 Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229

Pinto D:
 Department of Genetics and Genomic Sciences, Icahn School of Medicine At Mount Sinai, New York, NY 10029

Scherer SW:
 The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada

Alarcón-Riquelme ME:
 Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104

 Center for Genomics and Oncological Research, Pfizer-University of Granada-Andalusian Government, PTS Granada 18016, Spain

Docampo E:
 Interdisciplinary Cluster for Applied Genoproteomics-Université de Liège, 4000-Liège, Belgium

 Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain

Estivill X:
 Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, and Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain

Gül A:
 Istanbul Faculty of Medicine, Istanbul University, 34390 Istanbul, Turkey

de Bakker PI:
 Department of Epidemiology, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands

 Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands

 Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands

 and

Raychaudhuri S:
 Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT, United Kingdom

 Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142

 Division of Immunology, Allergy, and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115

Langefeld CD:
 Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, NC 27106

Thompson S:
 Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229

 Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229

Zeggini E:
 Human Genetics, The Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, United Kingdom

Thomson W:
 Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT, United Kingdom

 National Institute for Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester National Health Service Foundation Trust, Manchester Academic Health Centre, University of Manchester, Manchester, M13 9PT, United Kingdom

Kastner DL:
 Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892

 ombrellomj

Woo P:
 Center of Paediatric and Adolescent Rheumatology, University College London, London, WC1N 1EH, United Kingdom