Two-year Efficacy and Safety of Etanercept in Pediatric Patients with Extended Oligoarthritis, Enthesitis-related Arthritis, or Psoriatic Arthritis
Por:
Constantin T, Foeldvari I, Vojinovic J, Horneff G, Burgos-Vargas R, Nikishina I, Akikusa JD, Avcin T, Chaitow J, Koskova E, Lauwerys BR, Calvo Penades I, Flato B, Gamir ML, Huppertz HI, Raad JJ, Jarosova K, Anton-Lopez J, Macku M, Otero Escalante WJ, Rutkowska-Sak L, Trauzeddel R, Velez-Sanchez PJ, Wouters C, Wajdula J, Zang C, Bukowski J, Woodworth D, Vlahos B, Martini A, Ruperto N and Paediatric Rheumatology International Trials Organisation (PRINTO)
Publicada:
1 abr 2016
Resumen:
Objective. The main objective was to determine the 2-year clinical benefit and safety of etanercept (ETN) in children with the juvenile idiopathic arthritis (JIA) categories of extended oligoarthritis (eoJIA), enthesitis-related arthritis (ERA), or psoriatic arthritis (PsA).
Methods. CLIPPER was a 96-week, phase IIIb, open-label, multicenter study. Patients with eoJIA, ERA, or PsA received ETN 0.8 mg/kg once weekly (50 mg max) for up to 96 weeks. The proportions of patients reaching the JIA American College of Rheumatology (ACR) 30/50/70/90/100 and inactive disease responses at Week 96 were calculated. Adverse events (AE) were collected throughout the study (intention-to-treat sample).
Results. There were 127 patients (eoJIA n = 60, ERA n = 38, PsA n = 29) who received >= 1 dose of ETN. The mean disease duration was 31.6 (eoJIA), 23.0 (ERA), and 21.8 (PsA) months. At Week 96, JIA ACR 30/50/70/90/100/inactive disease responses (95% CI) were achieved by 84.3% (76.7, 90.1), 83.5% (75.8, 89.5), 78.7% (70.6, 85.5), 55.1% (46.0, 63.9), 45.7% (36.8, 54.7), and 27.6% (20.0, 36.2) of patients, respectively. The most common AE (no. events, events per 100 patient-yrs) overall were headache (23, 10.7), pyrexia (12, 5.6), and diarrhea (10, 4.6). The most common infections were upper respiratory tract infection (83, 38.6), pharyngitis (50, 23.2), gastroenteritis (22, 10.2), bronchitis (19, 8.8), and rhinitis (17, 7.9). No cases of malignancy, active tuberculosis, demyelinating disorders, or death were reported.
Conclusion. Over 96 weeks of therapy, ETN demonstrated sustained efficacy at treating the clinical symptoms of all 3 JIA categories, with no major safety issues.
Filiaciones:
Constantin T:
From the Paediatric Rheumatology International Trials Organisation (PRINTO), Istituto G. Gaslini, Pediatria II-Reumatologia, PRINTO, Genoa, Italy. Sponsored by Wyeth, which was acquired by Pfizer in October 2009. T. Constantin has received speaker's fees from or served as a consultant for Pfizer. J. Vojinovic has received honoraria from Pfizer. G. Horneff has received honoraria from Pfizer. I. Nikishina has received honoraria from Pfizer. T. Avcin has received speaker's bureau fees and honoraria
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
Foeldvari I:
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
Vojinovic J:
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
Horneff G:
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
Burgos-Vargas R:
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
Nikishina I:
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
Akikusa JD:
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
Avcin T:
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
Chaitow J:
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
Koskova E:
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
Lauwerys BR:
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
Calvo Penades I:
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
Flato B:
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
Gamir ML:
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
Huppertz HI:
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
Raad JJ:
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
Jarosova K:
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
Anton-Lopez J:
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
Macku M:
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
Otero Escalante WJ:
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
Rutkowska-Sak L:
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
Trauzeddel R:
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
Velez-Sanchez PJ:
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
Wouters C:
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
Wajdula J:
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
Zang C:
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
Bukowski J:
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
Woodworth D:
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
Vlahos B:
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
Martini A:
this money has been reinvested for the research activities of the hospital in a fully independent manner without any commitment to third parties. J. Wajdula, C. Zang, J. Bukowski, D. Woodworth, and B. Vlahos are all employees of Pfizer Inc. J. Wajdula is a Pfizer stockholder. T. Constantin, MD, PhD, 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
I. Foeldvari, MD, Hamburg Centre for Child and Adolescent Rheumatology, Hamburg, Germany
J. Vojinovic, MD, PhD, Clinic of Pediatrics, Clinical Centre, Faculty of Medicine, University of Nis, Serbia
G. Horneff, MD, Asklepios Clinic, Sankt Augustin, Germany
R. Burgos-Vargas, MD, Hospital General de Mexico, Mexico City, Mexico
I. Nikishina, MD, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
J.D. Akikusa, MD, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
T. Avcin, MD, PhD, University Medical Centre Ljubljana, Pediatric Clinic, Ljubljana, Slovenia
J. Chaitow, MD, The Sydney Children's Hospital Network, Westmead, Sydney, Australia
E. Koskova, MD, PhD, National Institute of Rheumatic Diseases, Piestany, Slovakia
B.R. Lauwerys, MD, PhD, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
I. Calvo Penades, MD, PhD, Hospital Universitario y Politécnico La Fe, Pediatric Rheumatology Unit, Valencia, Spain
B. Flato, MD, PhD, Oslo University Hospital, Department of Rheumatology, Oslo, Norway
M.L. Gamir, MD, Hospital Ramon y Cajal Unidad de Reumatologia Pediatrica, Madrid, Spain
H.I. Huppertz, MD, Klinikum Bremen-Mitte, Prof. Hess-Kinderklinik, Bremen, Germany
J.J. Raad, MD, Centro de Reumatologia y Ortopedia, Barranquilla, Atlantico, Colombia
K. Jarosova, MD, Revmatologicky Ustav, Prague, Czech Republic
J. Anton, MD, PhD, Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Espluges (Barcelona), Spain
M. Macku, MD, Fakultni nemocnice Brno, Bohunice, Detska Nemocnice, Ambulance detske revmatologie detske kliniky, Brno, Czech Republic
W.J. Otero Escalante, MD, Servimed S.A.S., Bucaramanga, Santander, Colombia
L. Rutkowska-Sak, MD, Instytut Reumatologii, Klinika i Poliklinika, Reumatologii Wieku, Rozwojowego, Warsaw, Poland
R. Trauzeddel, MD, HELIOS Klinikum Berlin-Buch Klinik für Kinder- und Jugendmedizin, Berlin, Germany
P.J. Velez- Sanchez, MD, Centro Integral de Reumatología e Inmunología SAS CIREI SAS, Bogotá, Cundinamarca, Colombia
C. Wouters, MD, PhD, UZ Leuven, Leuven, Belgium
J. Wajdula, PhD, Senior Director, Pfizer Inc
C. Zang, PhD, Associate Director, Pfizer Inc
J. Bukowski, MD, PhD, Director, Pfizer Inc
D. Woodworth, MS, Director, Pfizer Inc
B. Vlahos, MBA, BSN, RN, Senior Director, Pfizer Inc
A. Martini, MD, University of Genoa, Department of Pediatrics, Genoa, and Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO
N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II-Reumatologia, PRINTO. Address correspondence to Dr. N. Ruperto, Istituto G. Gaslini, Pediatria II, Reumatologia, PRINTO, Via G. Gaslini 5, Genoa 16147, Italy. E-mail:
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