Streptococcus pneumoniae carriage among healthy and sick pediatric patients before the generalized implementation of the 13-valent pneumococcal vaccine in Morocco from 2010 to 2011
Por:
Jroundi I, Mahraoui C, Benmessaoud R, Moraleda C, Munoz-Almagro C, Seffar M, Tligui H, Kettani SC, Benjelloun BS, Alonso PL and Bassat Q
Publicada:
1 mar 2017
Ahead of Print:
23 mar 2016
Resumen:
Nasopharyngeal carriage studies provide insights into the local prevalence of circulating pneumococcal serotypes. These data are critical to vaccination monitoring, as they allow for the prediction and assessment of impact. Very little data are available on the carriage of pneumococcal serotypes in Morocco. Here, we describe the prevalence of Streptococcus pneumoniae carriage and serotype distribution among 697 pediatric patients with ages ranging from 2 to 59 months who were admitted to a Moroccan hospital with severe pneumonia, as well as 195 healthy infants and young children who were recruited at a vaccination clinic. Carriage rates were 40.5% (79/195) for healthy children and 22.8% (159/697) for sick children. The most commonly observed circulating serotypes included 6A, 6B and 19F, all of which are included in the current 13-valent anti-pneumococcal conjugate vaccine that was recently introduced in Morocco. Monitoring of circulating serotypes remains necessary after vaccine introduction to assess whether serotype replacement is occurring. (C) 2016 King Saud Bin Abdulaziz University for Health Sciences. Published by Elsevier Limited. All rights reserved.
Filiaciones:
Jroundi I:
ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB), Hospital Clinic - Universitat de Barcelona, Barcelona, Spain
Unit of Training and Research in Public Health, School of Medicine and Pharmacy of Rabat, University Mohamed V, Rabat, Morocco.
Mahraoui C:
Hopital d'Enfants de Rabat, Centre Hospitalier Universitaire Ibn Sina, Rabat, Morocco
Munoz-Almagro C:
University Hospital Sant Joan de Déu, Esplugues, Barcelona, Spain
Seffar M:
Hopital d'Enfants de Rabat, Centre Hospitalier Universitaire Ibn Sina, Rabat, Morocco
Tligui H:
Hopital d'Enfants de Rabat, Centre Hospitalier Universitaire Ibn Sina, Rabat, Morocco
Kettani SC:
Hopital d'Enfants de Rabat, Centre Hospitalier Universitaire Ibn Sina, Rabat, Morocco
Benjelloun BS:
Hopital d'Enfants de Rabat, Centre Hospitalier Universitaire Ibn Sina, Rabat, Morocco
Bassat Q:
ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB), Hospital Clinic - Universitat de Barcelona, Barcelona, Spain
Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique
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