Two cases of localized neuroblastoma with multiple segmental chromosomal alterations and metastatic progression


Por: Morales-La Madrid A, Nall M, Ouyang K, Minor A, Raca G, Kent P, Miller I, Schleiermacher G, Janoueix-Lerosey I and Cohn S
Publicada: 1 feb 2013
Resumen:
Surgery alone is curative for most children with localized MYCN-non-amplified neuroblastoma. However, 1015% will develop recurrent loco-regional disease, and very rarely, patients will relapse metastatically. Currently, it is not possible to predict which child with localized, MYCN-non-amplified neuroblastoma will develop disseminated disease. We report two children who presented with favorable biology, localized neuroblastoma and subsequently relapsed with metastatic disease after treatment with surgery. Whole-genome DNA copy number analyses performed on the diagnostic tumors identified 15 (case 1) and 8 (case 2) segmental chromosomal alterations. Further analysis of the prognostic value of whole-genome analysis in children with localized neuroblastoma is warranted. Pediatr Blood Cancer 2013;60:332335. (c) 2012 Wiley Periodicals, Inc.
ISSN: 15455009





PEDIATRIC BLOOD & CANCER
Editorial
WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ, Estados Unidos America
Tipo de documento: Article
Volumen: 60 Número: 2
Páginas: 332-335
WOS Id: 000312557600028
ID de PubMed: 22997192

FULL TEXT

imagen Submitted Version https://www.wiley.com/en-us/network/publishing/research-publishing/open-access/copyright-and-licensing-with-wiley

MÉTRICAS